Guinea Pig Hybridoma based Antibody Discovery Service

Creative Biolabs makes a breakthrough in guinea pig monoclonal antibody production service via hybridoma technology. Contrary to the disappointing rabbit hybridoma technology which has generally indicated low stability and productivity, our cutting-edge guinea pig hybridoma technique exploits a novel source of outbreeding non-murine immune repertoire with stable productivity.

Overview of Guinea Pig

The word "guinea pig" is synonymous with scientific experiments, and this animal model has been in use for about 200 years and was the first to be used to study infectious diseases such as tuberculosis and diphtheria, but much less is known about this species than many other laboratory animals. Guinea pig, as a representative model of tuberculosis, is considered the "gold standard" for preclinical studies of new drugs and vaccines, various administration methods, and safety evaluation. Guinea pig is an ideal source to generate antibodies for extreme allergic reactions or anaphylaxis research, and also be treated as an important model for the study of various infectious diseases, such as tuberculosis and diphtheria.

Our Guinea Pig for Monoclonal Antibody Production Service

Fig.1 Workflow for the production of monoclonal antibodies using guinea pigs.

Features of Our Service

High level, high affinity antibody
Very high rate of cell fusion
High-throughput analysis of mAbs combinations
Extensive in vitro and in vivo hybridoma screening and identification assays, such as ELISA, FACS, ICC, IHC, WB, flow cytometry

Order Process

We keep the ordering procedure as easy as possible. Please submit the following information to assist us in correlating your antigen with your order and accelerate the process:

Your Antigen
Concentration & Buffer Conditions of your Antigen
The application and function of the antibodies developed

Advantages of Guinea Pig for Hybridoma Production

Sequencing of the guinea pig genome has made it easy to raise monoclonal and polyclonal antibodies against guinea pig proteins.
Suitable monoclonal antibodies secreted by specific hybridoma cells as an alternative to a guinea pig or rabbit antisera are considered the most promising diagnostic reagents in terms of homogeneity and specificity, and themselves and peroxidase-labeled mab can be used as capture and detection antibodies, respectively.
Guinea pigs are more sensitive rodents and their immunological genes are more similar to humans than that of mice. Meanwhile, the phylogeny of a guinea pig is far from murine which enables it to recognize target proteins that are highly conserved among mice, rats, rabbits, and humans, or the proteins be recognized as self-antigen by murine.
For some small targets, such as antibiotics or toxins, that may fail to trigger an immune response in mice, rats, or humans, guinea pigs can be an alternative besides the choice of rabbit and sheep.

According to these properties, guinea pigs are considered with huge potential to generate novel target-specific monoclonal antibodies for a series of research and therapeutic studies.

As a well-recognized expert in antibody research, Creative Biolabs can proudly offer the unique guinea pig hybridoma technology to generate monoclonal guinea pig antibodies. Through fusing with our specific myeloma as a partner, guinea pig hybridoma can be developed with excellent stability and productivity. Our scientists are confident in developing guinea pig hybridoma that produces monoclonal antibodies with high affinity and specificity.

If you have any questions, please feel free to contact us, we welcome to discuss the project solutions with you further.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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