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CD22

CD22 (cluster of differentiation-22) is a cell surface sialic acid binding Ig-like lectin (SIGLEC2 or SIGLEC-2) that is involved in B-cell and B-cell interactions. It is mainly expressed on mature B cells and it is an immunoglobulin protein that contains six Ig-like C2-type domains and one Ig-like V-type domain in the extracellular portion for ligand binding and four cytoplasmic immunoreceptor tyrosine-based inhibitor motifs (ITIM) for downstream cellular signaling modulations.

CD22 interacts with ligands including Grb2, PTPN6, LYN, SHC1, and INPP5D with a high preference towards alpha-2,6-linked sialic acid. The ligand binding leads to the phosphorylation of CD22 cytoplasmic portion and mediates B cell receptor (BCR) signaling. Overall, CD22 is regarded as a regulatory molecule that tunes-down immune system activity and prevents the development of autoimmune diseases. Mutations and abnormal expressions of CD22 is often associated with refractory hematologic cancer and it is being exploited as a target for ADC-based immunotherapies using certain immunotoxins.

Entrez Gene ID: 933
UniProt ID: P20273

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-093 Anti-CD22 (hLL2)-SN-38 ADC Humanized Anti-CD22-antibody, hLL2 SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-177 Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC Anti-CD22 antibody, clone # 10F4v3 BMPEO (bis-maleimido-trioxyethylene glycol) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-180 Anti-CD22 (clone 5E8)-SMCC-DM1 ADC Anti-CD22 antibody, clone # 5E8 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-181 Anti-CD22 (clone 7A2)-SMCC-DM1 ADC Anti-CD22 antibody, clone # 7A2 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-182 Anti-CD22 (clone 10F4v1)-SMCC-DM1 ADC Humanized Anti-CD22 antibody, clone # 10F4v1 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-183 Anti-CD22 (clone 10F4v2)-SMCC-DM1 ADC Humanized Anti-CD22 antibody, clone # 10F4v2 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-184 Anti-CD22 (clone 10F4v2)-Mc-MMAF ADC Humanized Anti-CD22 antibody, clone # 10F4v2 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-185 Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC Humanized Anti-CD22 antibody, clone # 10F4v3 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-186 Anti-CD22 (clone 10F4v3)-Mc-MMAF ADC Humanized Anti-CD22 antibody, clone # 10F4v3 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-187 Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC Humanized Anti-CD22 antibody, clone # 10F4v3 SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-188 Anti-CD22 (clone 10F4v3)-Mc-VC-PABC-MMAE ADC Humanized Anti-CD22 antibody, clone # 10F4v3 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-189 Anti-CD22 (clone 10F4)-SMCC-DM1 ADC Anti-CD22 antibody, clone # 10F4 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-190 Anti-CD22 (clone RFB4)-SMCC-DM1 ADC Anti-CD22 antibody, clone # RFB4 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-191 Anti-CD22 (clone RFB4)-Mc-VC-PABC-MMAF ADC Anti-CD22 antibody, clone # RFB4 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-192 Anti-CD22 (clone RFB4)-Mc-MMAF ADC Anti-CD22 antibody, clone # RFB4 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-193 Anti-CD22 (clone RFB4)-Mc-VC-PABC-MMAE ADC Anti-CD22 antibody, clone # RFB4 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-195 Anti-CD22 (clone 10F4v1)-Mc-MMAF ADC Anti-CD22 antibody, clone # 10F4v1 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-216 Anti-CD22 (10F4v3)-Mc-VC-PABC-MMAE ADC Humanized Anti-CD22 lgG1 Antibody, 10F4v3 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-217 Anti-CD22 (10F4v3)-Mc-MMAF ADC Humanized Anti-CD22 lgG1 Antibody, 10F4v3 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-331 Anti-CD22 (clone RFB4)-MCC-DM1 ADC Chimeric Anti-CD22 Antibody, clone # RFB4 MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-332 Anti-CD22 (clone 10F4)-AcBut-Calicheamicin ADC Humanized Anti-CD22 Antibody  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin Inquiry
ADC-W-335 Anti-CD22-Mc-MMAF ADC Humanized Anti-CD22 Antibody Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-336 Anti-CD22-MCC-DM1 ADC Humanized Anti-CD22 Antibody MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-337 Anti-CD22 (Pinatuzumab)-Mc-VC-PABC-MMAE ADC Humanized Anti-CD22 Antibody, Pinatuzumab MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-338 Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC Humanized Anti-CD22 Antibody, Inotuzumab hydrazone calicheamicin Inquiry
ADC-W-339 Anti-CD22-DIBO-doxorubicin ADC Humanized Anti-CD22 Antibody, Inotuzumab DIBO (dibenzylcyclooctynol) doxorubicin Inquiry
ADC-W-461   Anti-CD22 (clone G5/44)-AcBut-CalichDMH ADC inotuzumab ozogamicin Humanized Anti-CD22 Antibody, clone # G5/44 AcBut (4-(4-acetylphenoxy)butanoic acid) CalichDMH Inquiry
ADC-W-484   Anti-CD22 (clone hu10F4)-MCC-DM1 ADC hu10F4-MCC-DM1 Humanized Anti-CD22 Antibody, hu10F4 MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-540 Anti-CD22-Mc-VC-PAB-NMS249 ADC Anti-CD22 Antibody mc-VC-PAB (proteaselabile maleimido-caproyl-valine-citrulline-para-amino-benzyloxy carbonyl ) NMS249 Inquiry
ADC-W-586 Anti-CD22 (clone HB22.7)-saporin ADC Anti-CD22 Antibody, clone # HB227 saporin Inquiry
ADC-W-625 Anti-CD22 (10F4v3)-SPP-DM1 ADC Humanized Anti-CD22 lgG1 Antibody, 10F4v3 SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-626 Anti-CD22 (10F4v3)-MCC-DM1 ADC Humanized Anti-CD22 lgG1 Antibody, 10F4v3 MCC (Maleimidomethyl cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-794 Anti-CD22 (Bectumomab)-SMCC-DM1 ADC Anti-CD22 IgG2a-Fab’ fragment , Bectumomab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-795 Anti-CD22 (Bectumomab)-SPDB-DM4 ADC Anti-CD22 IgG2a-Fab’ fragment , Bectumomab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-796 Anti-CD22 (Bectumomab)-MC-MMAF ADC Anti-CD22 IgG2a-Fab’ fragment , Bectumomab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-797 Anti-CD22 (Bectumomab)-MC-Vc-PAB-MMAE ADC Anti-CD22 IgG2a-Fab’ fragment , Bectumomab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-798 Anti-CD22 (Bectumomab)-MC-Vc-PAB-SN38 ADC Anti-CD22 IgG2a-Fab’ fragment , Bectumomab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-799 Anti-CD22 (Bectumomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Anti-CD22 IgG2a-Fab’ fragment , Bectumomab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-800 Anti-CD22 (Moxetumomab pasudotox)-SMCC-DM1 ADC Anti-CD22 Fv-disulfide stabilized antibody, Moxetumomab pasudotox SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-801 Anti-CD22 (Moxetumomab pasudotox)-SPDB-DM4 ADC Anti-CD22 Fv-disulfide stabilized antibody, Moxetumomab pasudotox SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-802 Anti-CD22 (Moxetumomab pasudotox)-MC-MMAF ADC Anti-CD22 Fv-disulfide stabilized antibody, Moxetumomab pasudotox MC (maleimidocaproyl) MMAF Inquiry
ADC-W-803 Anti-CD22 (Moxetumomab pasudotox)-MC-Vc-PAB-MMAE ADC Anti-CD22 Fv-disulfide stabilized antibody, Moxetumomab pasudotox MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-804 Anti-CD22 (Moxetumomab pasudotox)-MC-Vc-PAB-SN38 ADC Anti-CD22 Fv-disulfide stabilized antibody, Moxetumomab pasudotox MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-805 Anti-CD22 (Moxetumomab pasudotox)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Anti-CD22 Fv-disulfide stabilized antibody, Moxetumomab pasudotox MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-2521 Anti-CD22 (Inotuzumab)-SMCC-DM1 ADC Humanized Anti-CD22 IgG4-kappa antibody, Inotuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2522 Anti-CD22 (Inotuzumab)-SPDB-DM4 ADC Humanized Anti-CD22 IgG4-kappa antibody, Inotuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2523 Anti-CD22 (Inotuzumab)-MC-MMAF ADC Humanized Anti-CD22 IgG4-kappa antibody, Inotuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2524 Anti-CD22 (Inotuzumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-CD22 IgG4-kappa antibody, Inotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2525 Anti-CD22 (Inotuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-CD22 IgG4-kappa antibody, Inotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2526 Anti-CD22 (Inotuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-CD22 IgG4-kappa antibody, Inotuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-2527 Anti-CD22-SMCC-DM1 ADC Humanized Anti-CD22 IgG1 antibody SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2528 Anti-CD22-SPDB-DM4 ADC Humanized Anti-CD22 IgG1 antibody SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2529 Anti-CD22-MC-Vc-PAB-MMAE ADC Humanized Anti-CD22 IgG1 antibody MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2530 Anti-CD22-MC-Vc-PAB-SN38 ADC Humanized Anti-CD22 IgG1 antibody MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2531 Anti-CD22-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-CD22 IgG1 antibody MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-2532 Anti-CD22 (Pinatuzumab)-SMCC-DM1 ADC Humanized Anti-CD22 IgG1-kappa antibody, Pinatuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2533 Anti-CD22 (Pinatuzumab)-SPDB-DM4 ADC Humanized Anti-CD22 IgG1-kappa antibody, Pinatuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2534 Anti-CD22 (Pinatuzumab)-MC-MMAF ADC Humanized Anti-CD22 IgG1-kappa antibody, Pinatuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2535 Anti-CD22 (Pinatuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-CD22 IgG1-kappa antibody, Pinatuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2536 Anti-CD22 (Pinatuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-CD22 IgG1-kappa antibody, Pinatuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry

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