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Bacteria based Protein Expression Service

Creative Biolabs' newly-built facilities supporting a vast array of state-of-the-art equipment are leveraged by our experienced PhD-level scientists to deliver proteins to be expressed via microbial systems quickly and economically. Over the years, Creative Biolabs has developed many technologies to tackle hard-to-express and hard-to-dissolve proteins. The expression level can be greatly improved for almost all of the proteins. In addition, over 98% of the inclusion bodies can be refolded and solubilized by our proprietary protein refolding technology.

E. coli Expression System

The first choice for the expression of recombinant proteins is typically E. coli. Production of proteins in this bacterial strain is well-established, fast, and simple and usually provides high yields. E. coli is excellent for expressing proteins that are primarily cytosolic and do not require post-translational modifications. Sometimes, proteins expressed in E. coli form insoluble aggregates known as inclusion bodies. These can be refolded into active forms through protein refolding techniques. The E. coli expression system is a versatile and powerful tool in biotechnology, allowing for the efficient production of a wide array of proteins.

B. subtilis Expression System

Bacillus subtilis is a significant microorganism in the scientific research field. It has been developed as an attractive host for the production of recombinant proteins. Our Bacillus subtilis system is an ideal option for the expression of monomeric protein products. This system, combined with our patented fermentation protocols allows for fast process development and scale-up to support early clinical testing.

Case Studies of Our Bacteria based Protein Expression Service

Cell supernatant purification (Creative Biolabs original)Fig.1. The SDS-PAGE results of protein purified in E. coli cell supernatant in Case 1.
Lane 1: Targeted Protein; Lane 2: BSA.

Inclusion bodies purification (Creative Biolabs original)Fig.2. The SDS-PAGE results of protein purified in inclusion bodies in Case 2.
Lane 1: Targeted Protein; Lane 2: BSA.

If you have any questions about our bacteria-based protein expression service, please contact us.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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