Creative Biolabs provides comprehensive antibody analysis services to make the best understanding of interested antibody properties. We offer tailored solutions for antibody analysis to support drug discovery, manufacturing processes, and any other particular requirements.
Monoclonal antibodies have emerged as one of the most significant and effective therapeutic options in oncology, immunology, and anti-infection treatments due to their exceptional specificity in binding to specific antigens. However, the complexity of antibody products presents unique challenges in their development and manufacturing, necessitating careful monitoring of impurities, structural variants, modifications, affinity, and immunogenicity to ensure product stability and safety. This reality underscores the critical need for innovative analytical tools and services in the field. Fortunately, Creative Biolabs is just the chosen one who is able to meet clients' analytical needs by offering a wide range of services that have been specifically tailored to meet the quality analysis and high-throughput requirements of antibody therapeutic development projects.
Thermodynamic antibody property analysis is a crucial aspect of characterizing antibody-antigen interactions.
Isothermal Titration Calorimetry (ITC) | Differential Scanning Calorimetry (DSC) | Dual-Polarization Interferometry (DPI) | Biolayer Interferometry (BLI) | Surface Plasmon Resonance (SPR) | |
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Utilizes multiple advanced instruments and integrated analysis methods to deliver fully customizable characterization solutions.
An experienced scientific team follows standardized protocols, providing detailed data interpretation and comprehensive reports with quality assurance.
Combines thermodynamic and binding analysis techniques such as ITC, DSC, BLI, and SPR to ensure accuracy and depth in analysis.
Offers customized solutions, fast turnaround times, competitive pricing, strict confidentiality, and full technical support.
Adheres to GLP standards, with thorough quality control, validation protocols, and complete documentation support.
Provides a one-stop analysis solution, flexible service options, expert consultation, reliable results, and project management support.
Gain a thorough understanding of IgG antibodies, including their structure and function. This Infographic covers the essential aspects of IgG, from its Y-shaped configuration and antigen-binding capabilities to its subclasses. Explore how these antibodies are used in both research and therapeutic applications.
Learn moreInfluenza viruses can escape the vaccine-induced immune response caused by antigen drift. Here, the researchers described the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody MEDI8852, which reacts effectively with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy chain VH6-1 gene, which has high potency and breadth. At the same time, the antibody is effective in mice and ferrets. Fab crystallographic analysis of single or complex H5 or H7 HA proteins showed that MEDI8852 binds to a highly conserved epitope through coordinated movement of CDR, which contains hydrophobic grooves in the fusion domain and most of the fusion peptides, which makes it different from other structural feature cross-reactive antibodies. The results show that the neutralization breadth and efficacy of MEDI8852 make it have great potential in immunotherapy for influenza virus infection.
Kallewaard, Nicole L., et al. "Structure and function analysis of an antibody recognizing all influenza A subtypes." Cell 166.3 (2016): 596-608. 2.1. Distributed under Open Access license CC BY 4.0, without modification.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.