Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsScientists of Creative Biolabs have successfully built up a unique platform to develop high affinity bovine monoclonal antibodies with ultralong CDR3s.
The complementarity determining regions (CDRs) are most important structure parts on an antibody that recognize the antigen. In humans, the specificity of an antibody is mostly governed by the largest CDR, i.e. CDR H3. Compared with antibodies from other species, bovine antibodies are unusual in having exceptionally long CDR H3 loops; about 10% of bovine antibodies have ultralong CD3 H3 regions (35-60 AAs). Evidence has shown that antibodies with unusually long CDR H3 regions may be more effective in defense against disease than typical antibodies.
Fig. 1 Comparison
between Human antibody and bovine antibody.
Bioinformatic analysis of ultralong CDR3s in bovine antibodies reveals a remarkable complexity of cysteines, which enables these ultralong CDR H3s to fold into a diversity of minidomains. Correspondingly, crystal structure reveals that these CDR H3s form a very unusual architecture composed of a β strand "stalk" that supports a structurally diverse, disulfide-bonded "knob" domain that can be elicited to recognize defined antigens.
With such unique structural and functional property, these bovine antibodies hold great potential on those targets that haven't been successfully targeted by traditional antibodies, for example, the GPCRs, and thus provide new avenues for therapeutic antibody development.
Besides developing bovine antibodies with ultralong CDR3s, Creative Biolabs has also established a technology to raise human therapeutic antibodies with ultralong CDR3s.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
