Custom GPCR Specific Antibody Discovery Services

With rich experience in antibody discovery and membrane protein studies, experts from Creative Biolabs have launched a cutting-edge membrane protein antibody development platform. Particularly, we now provide all-around service of anti-GPCR membrane protein antibody discovery service against a variety of GPCR targets.

Introduction

Being the largest membrane receptor family, G-protein-coupled receptors (GPCRs) have more than 800 members, about 370 of which are regarded as important therapeutic targets in the clinic. Currently, there are about 30% of marketed drugs that exert the intended effects through modulation of GPCRs. Especially, antibodies against GPCRs are drawing increasing research interest due to their high specificity, high affinity, good developability, and low cytotoxicity in contrast to small molecules. However, due to the complicated structure and low expression level of most GPCRs, anti-GPCR antibody development is very challenging. To overcome these issues and save valuable time for our clients, Creative Biolabs has integrated multiple state-of-the-art technologies for robust antibody generation against GPCRs:

Anti-GPCR Antibody Discovery Using Hybridoma	Anti-GPCR Antibody Discovery by Phage Display Technology
Creative Biolabs has extensive experience in hybridoma technology. Our hybridoma platform offers both mouse and rat animal models to raise anti-GPCR antibodies. Vigorous immune response and high cell fusion efficacy can be guaranteed, followed by comprehensive screening of large candidate pools.	Creative Biolabs offers an all-around phage display library construction and library screening service. Equipped with this world-leading phage display platform, dozens of references can be tracked for whom we have successfully generated good antibodies.
Anti-GPCR Antibody Discovery through Premade Antibody Libraries	Anti-GPCR Antibody Discovery via Our Unique Platform
Creative Biolabs carries multiple well-tailored premade antibody libraries of various formats to fulfill your needs. These libraries have great capacity and diversity that are able to derive excellent antibody binders with affinity ranging from 10 nM to 10 pM.	Based on antigen-specific B cell sorting technology, this unique Native™ antibody discovery platform aims at developing native monoclonal antibodies with naturally paired heavy chain and light chain. Aided by this technology, we are capable of enriching a large pool of native anti-GPCR IgGs from immunized hosts within a short period of time.

Empowered by these approaches, Creative Biolabs is confident in offering the most professional support to our clients regarding anti-GPCR antibody development. In addition, our scientists are also offering comprehensive GPCR immunogen preparation services in diverse formats. With rich experiences in hundreds of successful cases, our skilled technical teams are capable of all kinds of troubleshooting throughout the process. Please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Online Inquiry

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: info@creative-biolabs.com