Custom Ion Channel Specific Antibody Discovery Service

Creative Biolabs has been long devoted to the membrane protein field for biophysical investigations, structural studies, and particularly antibody development. After years of efforts, our scientific team now provides professional anti-ion channel antibody discovery services via multiple state-of-the-art technologies.

Introduction

Ion channels play key roles in many biophysical and pathological procedures by modulating cellular functions such as cell migration, secretion, electrical excitability, gene transcription, etc. Like GPCRs, ion channels are important targets for drug discovery. However, ion channels generally have very sophisticated structures with multiple (usually more than 10) transmembrane domains, leading to huge challenges in immunogen preparation and antibody selection. Creative Biolabs has developed an integrated platform offering a one-stop service to generate highly specific, highly affinitive anti-ion channel antibodies. With rich experience in dealing with various ion channels, our scientists specialize in tailoring custom project outlines according to each specific requirement. Notably, incorporated with our powerful membrane protein platform, we provide a one-stop service of ion channel immunogen preparation in a variety of formats. More importantly, we apply versatile approaches to antibody development in a more efficient and convenient way.

Anti-Ion Channel Antibody Discovery Using Hybridoma	Anti-Ion Channel Antibody Discovery by Phage Display Technology
Mouse/rat hybridoma is a classic approach for mAb discovery against various targets. Our featured adjuvant and unique fusion agent promise fusion efficiency. We also have multiple high-throughput screening approaches to offer flexible choices. In addition, equipped with cutting-edge transgenic skills, Creative Biolabs has generated several brand-new humanized mice strains producing fully human antibodies, which is an extra powerful tool for therapeutic antibody development.	Phage display is another widely used high-throughput-directed screening technique via presenting antibody fragments (scFv or Fab) of interest on the surface of bacteriophages. Creative Biolabs has established a leading phage display platform for phage display library construction and screening from many host species. Of note, our staff scientists are specialized in applying various biopanning strategies that best facilitate the enrichment of desired binders.
Anti-Ion Channel Antibody Discovery through Premade Antibody Libraries	Anti-Ion Channel Antibody Discovery via Our Unique Platform
Bypassing the time-consuming animal immunization process, plenty of premade libraries are presented by Creative Biolabs to fulfill your needs. We have well-tailored premade libraries from human, mouse, rat, camelid, sharks, etc., with an overwhelming capacity of 10⁸ ~10¹⁰. Numerous excellent binders have been derived from these premade libraries, some of which have already entered the clinical stage.	Native B cell sorting is another attractive strategy to obtain anti-ion channel antibodies with naturally paired heavy chains and light chains. Based on our Native™ antibody discovery platform, more than 15 host species, including but not limited to human, mouse, monkey, chicken, can be used. Antibodies raised by the Native™ platform, due to in vivo affinity maturation, are proven to exert better performance in binding, functions, developability, etc.

Scientists from Creative Biolabs are always ready to offer professional assistance to support custom projects of ant-ion channel antibody discovery. Please don't hesitate to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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