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Anti-TPBG (V422C)-VC-MMAD ADC (CAT#: ADC-W-166)

This ADC product is comprised of an anti-TPBG monoclonal antibody (V422C) conjugated via a VC linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • TPBG
  • Alternative Names
  • M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
  • Target Entrez Gene ID
  • 7162
  • Overview
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.
  • Overview
  • Engineered Anti-TPBG antibody, V422C
  • Generic name
  • V422C
  • Species Reactivity
  • Human
  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAD (monomethyl auristatin D)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
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CAMouse™-Fully Human Antibody Generation Platform
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