1. Home
  2. Products
  3. Customized ADCs
  4. FGFR2
  5. Anti-FGFR2-MMAE ADC

Anti-FGFR2-MMAE ADC (CAT#: ADC-W-557)

This ADC product is comprised of an anti-FGFR2 monoclonal antibody conjugated via a linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC payload drug
  • Name
  • FGFR2
  • Alternative Names
  • FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein;
  • Target Entrez Gene ID
  • 2043
  • Overview
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Overview
  • Anti-FGFR2 Antibody
  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

Related Products

Published Data

+ Submit Publications

Submit a review or a question

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
Reviews
Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
Protocol

Customer Reviews and FAQs

There are currently no Customer reviews or questions for ADC-W-557. Click the button above to contact us or submit your feedback about this product.

Quick Links

ADC Toxins
Drug-linker Complexes
Customized ADCs
Anti-Ab ADCs

Other Products

Same Target Same Payload
CAT# Product Name Linker Payload
ADC-W-057 Anti-FGFR2 (clone 11722)-sulfo-SMCC-DM1 ADC sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-058 Anti-FGFR2 (clone 12422)-sulfo-SMCC-DM1 ADC sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-052 Anti-FGFR2 (clone 12433)-sulfo-SMCC-DM1 ADC sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-066 Anti-FGFR2 (clone 12433)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-059 Anti-FGFR2 (clone 12947)-sulfo-SMCC-DM1 ADC sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
CAT# Product Name Linker Payload
ADC-AA-052 Protein A-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-AA-011 anti-HIgG(Fc)Fab-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-W-465 Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC VC-PAB (valine-citrulline with PAB) MMAE (Monomethyl auristatin E)
ADC-AA-021 anti-MIgG(Fc)-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-AA-003 anti-HIgG(Fc)-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)

Online Inquiry

Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.