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Anti-FOLR1-S-S-Dox ADC

Anti-FOLR1-S-S-Dox ADC (CAT#: ADC-W-602)

Name: Anti-FOLR1-S-S-Dox ADC
SKU: ADC-W-602
Rating: 5 (1 reviews)

This ADC product is comprised of an anti-FOLR1 monoclonal antibody conjugated via a linker to Dox. The Dox is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Dox binds to DNA, causes DNA damage.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Name
FOLR1

Alternative Names
FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;

Target Entrez Gene ID
2348

Target UniProt ID
A0A024R5H1

Overview
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

Overview
Anti-FOLR1 Antibody

Species Reactivity
Human

Name
disulfide (“S-S”) linker

Description
Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulﬁde-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulﬁde isomerase, or similar enzymes, drugs can be released.

Name
doxorubicin

Description
Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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ADC Toxins

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CAT#	Product Name	Linker	Payload
ADC-W-562	Anti-FOLR1-DGN462 ADC	maleimide containing linkers	DGN462
ADC-W-402	Anti-FOLR1 (clone M9346A)-sulfo-SPDB-DM4 ADC	sulfo-SPDB	DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-1168	Anti-FOLH1 (Farletuzumab)-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF
ADC-W-516	Anti-FOLR1 (M9346A)-SPDB-DM4 ADC	SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)	DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-1169	Anti-FOLH1 (Farletuzumab)-MC-Vc-PAB-MMAE ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE

CAT#	Product Name	Linker	Payload
ADC-W-571	Anti-ERBB2 (Trastuzumab)-DOX ADC	thiomaleamicacids-p-aminobenzyloxycarbonyl	doxorubicin
ADC-W-376	Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC	β-glucuronide linker	doxorubicin
ADC-W-423	Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC	hydrazone	doxorubicin
ADC-W-600	Anti-EGFR-doxorubicin ADC	polyethylene glycol linker	doxorubicin
ADC-W-479	Anti-CD74-SMCC-Dox ADC	SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)	Doxorubicin

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