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Anti-HIgG(Fab)-C-MMAF ADC

Anti-HIgG(Fab)-C-MMAF ADC (CAT#: ADC-AA-064)

This ADC product is comprised of an anti-human IgG Fab-specific polyclonal antibody conjugated via a cleavable linker to MMAF.The antibody portion is a secondary antibody. Monomethyl auristatin F (MMAF) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Overview
The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.

Overview
Anti-human IgG Fab-specific polyclonal antibody

Species Reactivity
Human

Name
Cleavable linkers

Description
Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracel

Name
MMAF

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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Customer Reviews FAQ

Excellent

The Anti-HIgG(Fab)-C-MMAF ADC from Creative Biolabs demonstrated exceptional cytotoxicity in our studies, effectively inhibiting cell division. The MMAF conjugation provides potent therapeutic potential, making it a valuable tool for our research.

Excellent

Using the Anti-HIgG(Fab)-C-MMAF ADC, we observed precise antigen targeting with significant inhibition of tubulin polymerization. This product significantly advanced our therapeutic research efforts with its reliable performance.

Excellent

Creative Biolabs' Anti-HIgG(Fab)-C-MMAF ADC delivered strong, consistent results in our studies. The targeted delivery of MMAF was particularly effective, making it an indispensable tool for our antibody-drug conjugate research.

Excellent

In our antibody research, this ADC product provided outstanding results. The Anti-HIgG(Fab)-C-MMAF ADC from Creative Biolabs was highly effective in binding to antigens and delivering its cytotoxic payload.

Excellent

The Anti-HIgG(Fab)-C-MMAF ADC surpassed our expectations with its targeted action and powerful cytotoxicity. It's a well-designed ADC that has proven to be highly effective in our therapeutic research.

Excellent

The precision of the Anti-HIgG(Fab)-C-MMAF ADC in targeting specific antigens was impressive. It provided high efficacy in our cell division inhibition assays, making it a reliable choice for our ongoing research.

Q: 1: What is the composition of the Anti-HIgG(Fab)-C-MMAF ADC?
A: The Anti-HIgG(Fab)-C-MMAF ADC is composed of an anti-human IgG Fab-specific polyclonal antibody conjugated via a cleavable linker to Monomethyl auristatin F (MMAF). The antibody acts as a secondary antibody, and MMAF is a cytotoxic molecule that inhibits cell division by blocking tubulin polymerization.
Q: 2: What is the function of MMAF in this ADC product?
A: MMAF, or Monomethyl auristatin F, is a potent cytotoxic agent in the Anti-HIgG(Fab)-C-MMAF ADC. It functions by inhibiting cell division through the blockage of tubulin polymerization, ultimately leading to cell death. This mechanism is crucial for the targeted elimination of cells bound by the antibody.
Q: 3: What type of antibody is used in the Anti-HIgG(Fab)-C-MMAF ADC?
A: The antibody used in this ADC is a polyclonal antibody specific to the human IgG Fab fragment. It serves as a secondary antibody that specifically targets and binds to the Fab region of human IgG, allowing for precise delivery of the cytotoxic MMAF to the intended cells.
Q: 4: What are the potential applications of the Anti-HIgG(Fab)-C-MMAF ADC in research?
A: This ADC can be used in research for targeted cell elimination studies, especially in models where human IgG Fab fragments are of interest. It may also be valuable in developing therapeutic strategies against diseases where the Fab region of human IgG is implicated.
Q: 5: How does the Anti-HIgG(Fab)-C-MMAF ADC differ from other ADCs?
A: The Anti-HIgG(Fab)-C-MMAF ADC is unique in that it targets the Fab fragment of human IgG specifically, using a polyclonal antibody and a cleavable linker to deliver MMAF. This combination of components allows for precise targeting and efficient cytotoxicity against cells expressing the targeted antigen.

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Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-AA-017	anti-HIgG(Fab)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-018	anti-HIgG(Fab)-N-DM1 ADC	Noncleavable linkers	DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-AA-063	Anti-HIgG(Fab)-N-MMAF ADC	Noncleavable linkers	MMAF

CAT#	Product Name	Linker	Payload
WJY-0423-LS107	Protein A-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
WJY-0423-LS108	Protein G-Amanitin ADC	Cleavable linkers	Amanitin
ADC-AA-061	Anti-MIgG(Fc)-C-DX8951 ADC	Cleavable linkers	DX8952
ADC-AA-029	anti-MIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-021	anti-MIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-2567	Anti-MUC16 (Sofituzumab)-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF
ADC-W-2622	Anti-NCAM1 (Lorvotuzumab )-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF
ADC-W-2606	Anti-ITGB3 (Tadocizumab)-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF
ADC-W-2544	Anti-CD44 (Bivatuzumab)-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF
ADC-AA-063	Anti-HIgG(Fab)-N-MMAF ADC	Noncleavable linkers	MMAF

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