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Biotin-PEG-maleimide (PEG1-PEGn)

Biotin-PEG-maleimide (PEG1-PEGn) (CAT#: ADC-L-600)

Biotin-PEG-maleimide (PEG1-PEGn) is a linker for bio-conjugation that contains a biotin and a terminal maleimide group linked through a linear PEG chain.

Product Information

CAS NO
305372-39-8

Description
Biotin-PEG-maleimide (PEG1-PEGn) is a linker for bio-conjugation that contains a biotin and a terminal maleimide group linked through a linear PEG chain.

Molecular Weight
525.6

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Biotin-PEG-maleimide was an essential linker in our bio-conjugation assays. The biotin and maleimide groups facilitated efficient protein labeling, allowing us to achieve precise and stable conjugations.

Excellent

In our ADC research, Biotin-PEG-maleimide enhanced the stability of our drug conjugates. The PEG chain provided flexibility while maintaining strong bio-conjugation between the antibody and drug payload.

Excellent

We used Biotin-PEG-maleimide in several bio-conjugation experiments, and it worked efficiently to link proteins with small molecules. The PEG chain ensured solubility and reduced aggregation issues.

Excellent

Biotin-PEG-maleimide was indispensable in our bio-conjugation work. Its biotin group provided a reliable method for streptavidin binding, while the PEG chain minimized steric hindrance during conjugation.

Excellent

Biotin-PEG-maleimide provided a reliable means of conjugating proteins to biotinylated surfaces. Its linear PEG chain minimized non-specific binding and allowed for consistent experimental outcomes in our lab.

Q: 1: What is Biotin-PEG-maleimide, and what are its primary applications?
A: Biotin-PEG-maleimide is a bifunctional reagent used for bioconjugation, connecting thiol-containing molecules like proteins and antibodies to biotinylated structures, often for drug delivery or ADC development.
Q: 2: How does the maleimide group in Biotin-PEG-maleimide function in conjugation reactions?
A: The maleimide group reacts with thiol groups in proteins or peptides, forming stable thioether bonds, which are essential for the conjugation of biomolecules in ADCs and other drug delivery systems.
Q: 3: What are the typical lengths of PEG chains in Biotin-PEG-maleimide?
A: Biotin-PEG-maleimide comes in various PEG chain lengths (PEG1-PEGn), allowing researchers to choose the optimal length for solubility, flexibility, and reduced steric hindrance in their experiments.
Q: 4: Can Biotin-PEG-maleimide be used in multi-functional conjugates?
A: Yes, Biotin-PEG-maleimide can be used to create multifunctional conjugates, allowing for the attachment of multiple payloads or targeting moieties, improving the versatility of drug delivery systems.
Q: 5: How does PEG length in Biotin-PEG-maleimide affect its function in ADCs?
A: Longer PEG chains reduce steric hindrance and increase solubility, improving circulation time and reducing immune recognition, making it suitable for designing more stable ADCs.

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