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Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC (CAT#: ADC-W-423)

This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin. The doxorubicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, doxorubicin binds to DNA, causes DNA damage.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • BR96
  • Name
  • FUT3
  • Alternative Names
  • FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-f
  • Target Entrez Gene ID
  • 2525
  • Overview
  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
  • Overview
  • Anti-FUT3 lgG3 Antibody, clone # BR96
  • Clone #
  • BR96
  • Species Reactivity
  • Mouse
  • Name
  • hydrazone
  • Description
  • Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3-7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0-6.5) and lysosomal (pH 4.5-5.0) compartments of the cell.
  • Name
  • doxorubicin
  • Description
  • Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

For Research Use Only. NOT FOR CLINICAL USE.

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CAT# Product Name Linker Payload
ADC-W-604 Anti-FUT3 (clone BR96)-Mc-VC-PABC-MMAF ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F)
ADC-W-459 Anti-FUT3 (clone hu3S193)-AcBut-CalichDMH ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] CalichDMH
ADC-W-463 Anti-FUT3 (clone BR 96)-Mc-Dox ADC Mc (maleimidocaproyl) Doxorubicin
ADC-W-424 Anti-FUT3 (clone cBR96)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
ADC-W-338 Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC hydrazone calicheamicin
CAT# Product Name Linker Payload
ADC-W-571 Anti-ERBB2 (Trastuzumab)-DOX ADC thiomaleamicacids-p-aminobenzyloxycarbonyl doxorubicin
ADC-W-378 Anti-CD74-hindered disulfide-Doxorubicin ADC hindered disulfide doxorubicin
ADC-W-503 Anti-EGFR-EDC/NHS-Dox ADC EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide) Doxorubicin
ADC-W-581 Anti-EpCAM (MOC31)-hydrazone-Doxorubicin ADC acid-cleavable hydrazone linker doxorubicin
ADC-W-479 Anti-CD74-SMCC-Dox ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) Doxorubicin

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