1. Home
  2. Products
  3. Customized ADCs
  4. TACSTD2
  5. Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-MMAD ADC

Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-MMAD ADC (CAT#: ADC-W-290)

This ADC product is comprised of an anti-TACSTD2 monoclonal antibody (clone 7E6) conjugated via a AcLys-VC-PABC linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • 7E6
  • Name
  • TACSTD2
  • Alternative Names
  • TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic ca
  • Target Entrez Gene ID
  • 4070
  • Overview
  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
  • Overview
  • Chimeric Anti-TACSTD2 antibody, clone # 7E6
  • Clone #
  • 7E6
  • Species Reactivity
  • Human
  • Name
  • AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl)
  • Name
  • MMAD (monomethyl auristatin D)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

Related Products

Published Data

+ Submit Publications

Submit a review or a question

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
Reviews
Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
Protocol

Customer Reviews and FAQs

There are currently no Customer reviews or questions for ADC-W-290. Click the button above to contact us or submit your feedback about this product.

Quick Links

ADC Toxins
Drug-linker Complexes
Customized ADCs
Anti-Ab ADCs

Other Products

Same Payload Same Target Same Linker
CAT# Product Name Linker Payload
ADC-W-166 Anti-TPBG (V422C)-VC-MMAD ADC VC (valine-citrulline) MMAD (monomethyl auristatin D)
ADC-W-292 Anti-TACSTD2 (clone 7E6)-PEG6-MMAD ADC PEG6 ((Propylene Glycol)-6-propionyl) MMAD (monomethyl auristatin D)
ADC-W-538 Anti-TACSTD2 (clone C16)-PEG6-MMAD ADC Amino-PEG6-based linker MMAD (monomethyl auristatin D)
ADC-W-409 Anti-ERBB2 (Trastuzumab)-Mc-MMAD ADC Mc (maleimidocaproyl) MMAD (monomethyl auristatin D)
ADC-W-408 Anti-ERBB2 (Trastuzumab)-MMAD ADC Non-Cleavable hydroxyl amino PEG linker MMAD (monomethyl auristatin D)
CAT# Product Name Linker Payload
ADC-W-292 Anti-TACSTD2 (clone 7E6)-PEG6-MMAD ADC PEG6 ((Propylene Glycol)-6-propionyl) MMAD (monomethyl auristatin D)
ADC-W-570 Anti-TACSTD2 (clone C16)-Mc-VC-MMAD ADC Mc-VC (maleimidocaproyl-valine-alanine) MMAD (monomethyl auristatin D)
ADC-W-538 Anti-TACSTD2 (clone C16)-PEG6-MMAD ADC Amino-PEG6-based linker MMAD (monomethyl auristatin D)
ADC-W-539 Anti-TACSTD2 (clone C16)-PEG6-Aur3377 ADC Amino-PEG6-based linker Aur3377
ADC-W-568 Anti-TACSTD2 (clone C16)-VC-MMAD ADC VC (valine-citrulline) MMAD (monomethyl auristatin D)
CAT# Product Name Linker Payload
ADC-W-293 Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-0101 AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) 2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide)

Online Inquiry

Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.