DGN549 (CAT#: ADC-S-052)

Linker-Toxin SET, this set is made by PBD dimer conjugated to the lysosomally cleavable dipeptide, valine-alanine (va) linker. PBDs are a class of DNA-crosslinking agents that are significantly more potent than systemic chemotherapeutic drugs.

Product Information

Description
Linker-Toxin SET, this set is made by PBD dimer conjugated to the lysosomally cleavable dipeptide, valine-alanine (va) linker. PBDs are a class of DNA-crosslinking agents that are significantly more potent than systemic chemotherapeutic drugs.

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

The DGN549 linker-toxin set provided exceptional potency in our ADC research. The PBD dimer's ability to crosslink DNA, combined with the cleavable va linker, made it a powerful tool for targeted cancer therapy.

Excellent

Excellent product!

DGN549 delivered strong, reliable results in our studies. The PBD dimer, conjugated with the valine-alanine linker, provided potent DNA crosslinking effects, significantly advancing our research.

Excellent

The DGN549 set from Creative Biolabs offered impressive efficacy in our experiments. The PBD dimer's high potency and the cleavable va linker worked perfectly, leading to effective and targeted cytotoxicity.

Excellent

The DGN549 product exceeded our expectations, delivering strong and consistent results in our studies. The combination of PBD dimer and cleavable va linker was particularly effective for our ADC development.

Excellent

We were very satisfied with the DGN549 linker-toxin set. It delivered potent DNA crosslinking and targeted cytotoxicity, significantly advancing our cancer therapy studies. Highly recommended!

Excellent

Great product for ADC research!

The DGN549 linker-toxin set offered the DNA crosslinking potency we required, with the added precision of the cleavable va linker. It's a top choice for developing potent ADCs.

Q: 1: What is DGN549, and how is it used in antibody-drug conjugates?
A: DGN549 is a linker-toxin set composed of a PBD (pyrrolobenzodiazepine) dimer conjugated to a lysosomally cleavable valine-alanine (va) linker. PBD dimers are potent DNA-crosslinking agents, making DGN549 an effective component in ADCs for targeted cancer therapy.
Q: 2: What makes PBD dimers more potent than traditional chemotherapeutic drugs?
A: PBD dimers are significantly more potent than traditional systemic chemotherapeutic drugs due to their ability to form DNA crosslinks, which effectively disrupts DNA replication and transcription, leading to cell death. This high potency allows for lower drug doses, reducing systemic toxicity while maintaining therapeutic efficacy.
Q: 3: What types of cancer cells are most responsive to treatments using DGN549?
A: Cancer cells that are sensitive to DNA crosslinking agents are most responsive to treatments using DGN549. PBD dimers are effective in a wide range of cancers, including solid tumors and hematological malignancies, particularly those that are resistant to traditional chemotherapy.
Q: 4: How does the potency of PBD dimers affect the dosing strategies for ADCs using DGN549?
A: Due to the high potency of PBD dimers, ADCs using DGN549 can be administered at lower doses compared to traditional chemotherapeutics. This allows for effective treatment while reducing the risk of systemic toxicity, making it an ideal option for targeted cancer therapies.
Q: 5: Can DGN549 be used in combination with other ADC components for enhanced therapeutic effects?
A: Yes, DGN549 can be used in combination with other ADC components, such as different antibodies or linkers, to enhance therapeutic effects. Researchers can explore various combinations to optimize the efficacy, specificity, and safety of the ADC for specific cancer types.

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