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Doxorubicin hydrochloride

Doxorubicin hydrochloride (CAT#: ADC-P-014)

ADCs cytotoxin, Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Product Information

CAS NO
25316-40-9

Description
ADCs cytotoxin, Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Classification
DNA Inhibitors

Molecular Weight
579.98

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Customer Reviews FAQ

Excellent

This compound has significantly contributed to my research on DNA topoisomerase II inhibition. Doxorubicin hydrochloride consistently showed potent effects, leading to clear apoptosis in my cancer cell models.

Excellent

Doxorubicin hydrochloride from Creative Biolabs has been essential in my apoptosis studies. It effectively induces DNA damage, making it a powerful tool for understanding cell death pathways in cancer cells.

Excellent

In my ADC research, Doxorubicin hydrochloride served as an effective cytotoxic payload. It allowed the antibody-drug conjugates to deliver strong anti-tumor activity with remarkable specificity.

Excellent

This compound performed well in inducing apoptosis in my cancer cell line experiments. Doxorubicin hydrochloride provided robust and consistent data, helping to advance my studies on targeted therapies.

Excellent

I used Doxorubicin hydrochloride as the cytotoxic payload in my ADC studies, and it significantly boosted the efficacy of the conjugates. The compound's ability to induce apoptosis ensured highly effective cancer cell eradication.

Q: 1: What is Doxorubicin hydrochloride, and what is it used for?
A: Doxorubicin hydrochloride is a widely used anthracycline antibiotic for cancer therapy, known for its DNA intercalation properties, making it essential in both chemotherapy and ADC development.
Q: 2: How stable is Doxorubicin hydrochloride in ADC formulations?
A: Doxorubicin hydrochloride is stable when attached via a cleavable linker in ADCs, ensuring controlled release inside the tumor environment without premature degradation.
Q: 3: How does Doxorubicin hydrochloride induce apoptosis in cancer cells?
A: Doxorubicin hydrochloride intercalates into DNA, inhibiting topoisomerase II, which prevents DNA replication and transcription, ultimately triggering apoptosis in rapidly dividing cancer cells.
Q: 4: How does Doxorubicin hydrochloride improve the therapeutic index of ADCs?
A: By targeting cancer cells specifically through antibodies, Doxorubicin hydrochloride-based ADCs improve the therapeutic index by maximizing drug efficacy while reducing off-target toxicity.
Q: 5: Does Creative Biolabs offer custom services for Doxorubicin hydrochloride ADC development?
A: Yes, Creative Biolabs provides custom ADC development services using Doxorubicin hydrochloride, allowing researchers to create targeted therapies for specific cancer applications.

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