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Epothilone A (CAT#: ADC-P-048)
ADCs Toxins, Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells).Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B.
- Product Information
- Description
- ADCs Toxins, Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells).Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B.
- Classification
- Microtubule Inhibitors
- Molecular Weight
- 493.7
- Purity
- 95%
For Research Use Only. NOT FOR CLINICAL USE.
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Customer Reviews
FAQ
Excellent
Epothilone A proved to be an effective compound in our cancer cell assays, particularly showing significant cytotoxicity against T-24 bladder carcinoma cells. Its tubulin polymerization ability was impressive in stabilizing microtubules.
Excellent
In our ADC research, Epothilone A was an exceptional cytotoxic agent. Its ability to target multidrug-resistant cells made it invaluable in enhancing the efficacy of antibody-drug conjugates.
Excellent
When using Epothilone A in ADC development, its cytotoxic effects were apparent, especially against multidrug-resistant cells. The compound showed promise in enhancing drug delivery systems for targeted therapies.
Excellent
I tested Epothilone A in multidrug-resistant cell lines and observed superior cytotoxic effects compared to paclitaxel. This compound is especially potent against cells expressing P-glycoprotein.
Excellent
Our lab employed Epothilone A in ADC experiments, and its efficacy against MDR cells was impressive. Its microtubule-stabilizing properties made it an ideal choice for our conjugate development.
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