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Geldanamycin (CAT#: ADC-P-092)
ADCs Toxins, Geldanamycin is a benzoquinone ansamycin antibiotic. Geldamycin is among other things used to cure cancer patients. It specifically ties up to the heat shock proteine HSP 90 (Heat Shock Protein 90) and changes its function. The bond of Geldamycin to HSP 90 causes the decomposition of target-proteins such as Tyrosinkinasen, Steroidrezeptoren, Transkriptionsfactors and cell-cycle regulative Kinasen. It induces the inactivation, destabilisation and finally the decomposition of HIF-1a. An extremely interesting research reagent for the biotechnology industry Origin: Streptomyces Hygroscopicus var Geldanus
- Product Information
- CAS NO
- 30562-34-6
- Description
- ADCs Toxins, Geldanamycin is a benzoquinone ansamycin antibiotic. Geldamycin is among other things used to cure cancer patients. It specifically ties up to the heat shock proteine HSP 90 (Heat Shock Protein 90) and changes its function. The bond of Geldamycin to HSP 90 causes the decomposition of target-proteins such as Tyrosinkinasen, Steroidrezeptoren, Transkriptionsfactors and cell-cycle regulative Kinasen. It induces the inactivation, destabilisation and finally the decomposition of HIF-1a. An extremely interesting research reagent for the biotechnology industry Origin: Streptomyces Hygroscopicus var Geldanus
- Classification
- Hsp90 Inhibitors
- Molecular Weight
- 560.64
- Purity
- 95%
For Research Use Only. NOT FOR CLINICAL USE.
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Customer Reviews
FAQ
Excellent
Geldanamycin proved highly effective in our cancer cell studies by targeting HSP90. Its ability to degrade key signaling proteins like tyrosine kinases significantly impacted cell proliferation, offering new avenues for therapeutic research.
Excellent
We employed Geldanamycin in our ADC research, and it enhanced the efficacy of our conjugates by destabilizing crucial proteins within cancer cells. This improved the therapeutic outcomes of our antibody-drug conjugates.
Excellent
In our ADC development, Geldanamycin demonstrated its potent effects by disrupting HSP90 function. This, in turn, helped amplify the cytotoxic effects of our conjugated drugs, leading to improved results.
Excellent
We observed excellent results using Geldanamycin in our ADC assays. Its role in destabilizing key proteins made it a perfect companion for enhancing the efficacy of our cytotoxic conjugates.
Excellent
Geldanamycin's impact on steroid receptors in our studies was profound. It not only altered receptor function but also promoted their degradation, making it a crucial reagent for hormone-related cancer research.
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