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- Anti-TPBG (clone H8)-AcBut-CalichDMH ADC
Anti-TPBG (clone H8)-AcBut-CalichDMH ADC (CAT#: ADC-W-197)
This ADC product is comprised of an anti-TPBG monoclonal antibody (clone H8) conjugated via a AcBut linker to CalichDMH. The CalichDMH is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, CalichDMH binds to DNA, causes DNA damage.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- Murine H8 Antibody
- Name
- TPBG
- Alternative Names
- M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
- Target Entrez Gene ID
- 7162
- Target UniProt ID
- Q13641
- Overview
- This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.
- Overview
- Anti-TPBG antibody, clone # Murine H8
- Clone #
- Murine H8 Antibody
- Host animal
- Mouse
- Species Reactivity
- Human
- Name
- AcBut (4-(4'acetylphenoxy)butanoic acid)
- Description
- Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
- Name
- CalichDMH (Calicheamicin (CM))
- Description
- Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-162 | Anti-TPBG ( L443C)-Mc-MMAD ADC | Mc (maleimidocaproyl) | MMAD (monomethyl auristatin D) |
| ADC-W-166 | Anti-TPBG (V422C)-VC-MMAD ADC | VC (valine-citrulline) | MMAD (monomethyl auristatin D) |
| ADC-W-007 | Anti-TPBG (clone A3)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-198 | Anti-TPBG (clone H8)-AcPac-CalichDMH ADC | AcPac (3-acetylphenyl acidic acid) | CalichDMH (Calicheamicin (CM)) |
| ADC-W-159 | Anti-TPBG ( E380C)-Mc-MMAD ADC | Mc (maleimidocaproyl) | MMAD (monomethyl auristatin D) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-198 | Anti-TPBG (clone H8)-AcPac-CalichDMH ADC | AcPac (3-acetylphenyl acidic acid) | CalichDMH (Calicheamicin (CM)) |
| ADC-W-199 | Anti-TPBG (clone H8)-Amide-CalichDMH ADC | Amide (4-mercapto-4-methyl-pentanoic acid) | CalichDMH (Calicheamicin (CM)) |
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