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- anti-HIgG(Fab)-C-MMAE ADC
anti-HIgG(Fab)-C-MMAE ADC (CAT#: ADC-AA-017)
This ADC product is comprised of an anti-human IgG Fab specific polyclonal antibody conjugated via a cleavable linker to MMAE. The antibody portion is a secondary antibodyand the drug portion, MMAE, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG Fab
- Overview
- The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.
- Overview
- anti-human IgG Fab specific polyclonal IgG antibody
- Species Reactivity
- Human
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-AA-017. Click the button above to contact us or submit your feedback about this product.
Customer Reviews
FAQ
Excellent
Highly Effective and Reliable The MMAE component effectively induced cell death with precise microtubule disruption. A great choice for pre-screening human monoclonal antibodies.
Excellent
Outstanding Specificity The anti-human IgG Fab specificity was impressive. The cleavable linker provided excellent stability and performance in our assays.
Excellent
Exceptional Quality This ADC delivered consistent and high-quality results, significantly enhancing our research outcomes. No observable toxicity without the primary antibody.
Excellent
Efficient and Economical A cost-effective solution for our ADC candidate screenings. The product's efficiency and performance exceeded our expectations.
Excellent
Impressive Results The Fab fragment targeting and MMAE's cytotoxicity combined seamlessly to provide clear and reproducible results in our experiments.
Excellent
Robust and Versatile The ADC showed robust performance across various tests. The cleavable linker and MMAE component ensured precise and effective cell targeting.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-064 | Anti-HIgG(Fab)-C-MMAF ADC | Cleavable linkers | MMAF |
| ADC-AA-063 | Anti-HIgG(Fab)-N-MMAF ADC | Noncleavable linkers | MMAF |
| ADC-AA-018 | anti-HIgG(Fab)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-064 | Anti-HIgG(Fab)-C-MMAF ADC | Cleavable linkers | MMAF |
| WJY-0423-LS107 | Protein A-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-066 | Anti-Rat IgG(H+L)-C-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-499 | Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC | mc-VC-PABC | MMAE (Monomethyl auristatin E) |
| ADC-W-536 | Anti-EDNRB (endothelin B)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-011 | anti-HIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-056 | Anti-MIgG (clone 187.1)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
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