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Anti-SLC34A2 (Lifastuzumab )-MC-MMAF ADC (CAT#: ADC-W-2573)

This ADC product is comprised of an anti-SLC34A2 monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • SLC34A2
  • Alternative Names
  • SLC34A2; solute carrier family 34 (type II sodium/phosphate contransporter), member 2; NPTIIb; NAPI-3B; NAPI-IIb; sodium-dependent phosphate transport protein 2B; sodium/phosphate cotransporter 2B; type II sodium-dependent phosphate transporter 3b; solute carrier family 34 (sodium phosphate), member 2;
  • Target Entrez Gene ID
  • 10568
  • Overview
  • The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.
  • Overview
  • Human Anti-SLC34A2 IgG1-kappa antibody, Lifastuzumab
  • Generic name
  • Lifastuzumab
  • Host animal
  • Human
  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
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CAMouse™-Fully Human Antibody Generation Platform
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ADC-W-499 Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC mc-VC-PABC MMAE (Monomethyl auristatin E)
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ADC-W-2572 Anti-SLC34A2 (Lifastuzumab )-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-2574 Anti-SLC34A2 (Lifastuzumab )-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
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CAT# Product Name Linker Payload
ADC-W-2550 Anti-CD74-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-AA-063 Anti-HIgG(Fab)-N-MMAF ADC Noncleavable linkers MMAF
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ADC-AA-064 Anti-HIgG(Fab)-C-MMAF ADC Cleavable linkers MMAF

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