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anti-MIgG(Fc)-C-MMAE ADC

anti-MIgG(Fc)-C-MMAE ADC (CAT#: ADC-AA-021)

This ADC product is comprised of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MMAE. The antibody portion is a secondary antibody and the drug portion, MMAE, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening mouse monoclonal antibodies as ADC candidates.

ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Name
IgG Fc

Overview
The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.

Overview
anti-mouse IgG Fc specific polyclonal IgG antibody

Species Reactivity
Mouse

Name
Cleavable linkers

Description
Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulﬁde-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.

Name
MMAE (Monomethyl auristatin E)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Creative Biolabs' anti-MIgG(Fc)-C-MMAE ADC has been exceptional in our ADC development pipeline. The MMAE component effectively disrupts microtubules, leading to targeted cell death with minimal off-target effects.

Excellent

Using the anti-MIgG(Fc)-C-MMAE ADC has streamlined our pre-screening of mouse monoclonal antibodies. Its precision and low toxicity make it an indispensable tool in our lab.

Excellent

The specificity and efficiency of the anti-MIgG(Fc)-C-MMAE ADC have significantly enhanced our research outcomes. The cleavable linker provides precise delivery of MMAE, improving safety and effectiveness.

Excellent

I highly recommend this ADC for researchers looking for an economical yet powerful option for targeting and killing cancer cells in mouse models. It delivers MMAE with great precision.

Excellent

Our results with the anti-MIgG(Fc)-C-MMAE ADC have been very promising. It offers a potent and targeted approach to induce apoptosis in cancer cells, which is crucial for our studies.

Excellent

This product from Creative Biolabs provides reliable and reproducible results in our experiments targeting specific cells. The MMAE conjugation through a cleavable linker is particularly effective.

Q: 1: What is anti-MIgG(Fc)-C-MMAE ADC?
A: Anti-MIgG(Fc)-C-MMAE ADC is a conjugate composed of an anti-mouse IgG Fc specific polyclonal antibody linked via a cleavable linker to the cytotoxic agent MMAE. It serves as a secondary antibody for pre-screening mouse monoclonal antibodies as ADC candidates.
Q: 2: How does MMAE function in anti-MIgG(Fc)-C-MMAE ADC?
A: MMAE is a cytotoxic small molecule that binds to tubulins, disrupting microtubule dynamics, and inducing cell death. In the ADC, MMAE's cytotoxic effects are targeted to specific cells through the antibody component.
Q: 3: What are the key differences between MMAE and MMAF in ADCs?
A: Both MMAE and MMAF are cytotoxic agents used in ADCs, but MMAE is generally considered to have higher cell permeability compared to MMAF. This difference can affect the choice of drug depending on the specific application and target cells.
Q: 4: What is the role of the Fc region in anti-MIgG(Fc)-C-MMAE ADC?
A: The Fc region of the IgG molecule is crucial for Fc receptor-mediated activity. It binds to various cell receptors and complement proteins, mediating physiological effects such as opsonization, antibody-dependent cellular cytotoxicity (ADCC), and the degranulation of immune cells.
Q: 5: Can anti-MIgG(Fc)-C-MMAE ADC be used in combination with other therapeutic agents?
A: While primarily used for pre-screening mouse monoclonal antibodies, anti-MIgG(Fc)-C-MMAE ADC can potentially be used in combination with other therapeutic agents in research settings to evaluate synergistic effects and optimize ADC formulations.
Q: 6: What are the potential applications of anti-MIgG(Fc)-C-MMAE ADC in research?
A: This ADC is used for pre-screening mouse monoclonal antibodies, facilitating the development of new ADCs. Its application extends to studying ADC mechanisms, optimizing ADC formulations, and evaluating the cytotoxic effects of different drug-linker combinations.

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Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-AA-052	Protein A-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-049	Protein G-MMAF ADC		MMAF (Monomethyl auristatin F)
ADC-AA-029	anti-MIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-050	Protein G-MCC-DM1 ADC	MCC (Maleimidomethyl cyclohexane-1-carboxylate)	DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-AA-056	Anti-MIgG (clone 187.1)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
WJY-0423-LS107	Protein A-PBD ADC	Cleavable linkers	PBD (pyrrolobenzodiazepine)
ADC-AA-003	anti-HIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-062	Anti-HIgG(Fc)Fab-C-DX8951 ADC	Cleavable linkers	DX8953
ADC-AA-028	anti-MIgG(Fc)Fab-C-MMAF ADC	Cleavable linkers	MMAF (Monomethyl auristatin F)
ADC-AA-029	anti-MIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-499	Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC	mc-VC-PABC	MMAE (Monomethyl auristatin E)
ADC-AA-003	anti-HIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-052	Protein A-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-564	Anti-MUC16-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-056	Anti-MIgG (clone 187.1)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

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