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- Protein G-Amanitin ADC
Protein G-Amanitin ADC (CAT#: WJY-0423-LS108)
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Overview
- The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
- Species Reactivity
- Human; Mouse; Rat
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- Amanitin
- Description
- α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
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Customer Reviews
FAQ

Excellent
Highly effective ADC! The Protein G-Amanitin ADC demonstrated excellent specificity and potent cytotoxicity in our cancer cell assays. The product's reliability significantly enhanced our research outcomes.

Excellent
Exceptional results! The Protein G-Amanitin ADC delivered strong, targeted effects with minimal off-target toxicity. This product has been a valuable addition to our ADC research toolkit.

Excellent
Impressive performance! The Protein G-Amanitin ADC worked flawlessly in our lab, providing precise targeting and potent cytotoxicity. The product's quality was evident in the consistent results we achieved.

Excellent
Great product! The Protein G-Amanitin ADC offered strong binding and effective cell death induction in our studies. It was a crucial component in our research, delivering the results we needed.

Excellent
Effective and reliable! The Protein G-Amanitin ADC from Creative Biolabs demonstrated outstanding cytotoxicity with minimal off-target effects. This product was crucial for our cancer cell research.
Quick Links
Other Products
Same Target
Same Linker
CAT# | Product Name | Linker | Payload |
ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
ADC-AA-054 | Protein A-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
CAT# | Product Name | Linker | Payload |
WJY-0423-LS106 | Protein A-Calicheamicin ADC | Cleavable linkers | Calicheamicin |
WJY-0423-LS107 | Protein A-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
ADC-AA-003 | anti-HIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
ADC-AA-061 | Anti-MIgG(Fc)-C-DX8951 ADC | Cleavable linkers | DX8952 |
ADC-AA-066 | Anti-Rat IgG(H+L)-C-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
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