Protein G-Amanitin ADC (CAT#: WJY-0423-LS108)

A: The Protein G-Amanitin ADC is composed of Protein G conjugated to the potent toxin Amanitin. Protein G binds to the Fc region of antibodies, facilitating the targeted delivery of Amanitin to specific cells. Amanitin is a toxin that inhibits RNA polymerase II, leading to cell death.

A: Amanitin functions by inhibiting RNA polymerase II, a critical enzyme involved in mRNA synthesis. When delivered into target cells by the Protein G-Amanitin ADC, Amanitin disrupts the transcription process, ultimately leading to apoptosis or programmed cell death.

A: Yes, Creative Biolabs offers customization services for the Protein G-Amanitin ADC. Researchers can request modifications to the linker, conjugation process, or specific components to suit their experimental needs, allowing for tailored solutions that align with their research objectives.

A: Creative Biolabs ensures the quality and reliability of this ADC through rigorous quality control measures, including purity analysis, conjugation efficiency testing, and cytotoxicity assays. Each batch of ADC undergoes extensive testing to meet the high standards required for research applications, providing researchers with consistent and dependable results.

A: Protein G-Amanitin ADC can be applied in cancer research for the development of targeted therapies, particularly in models where Fc receptor expression is relevant. It is a valuable tool for studying the effects of RNA polymerase II inhibition in cancer cells, as well as for screening potential monoclonal antibodies that could be used in conjunction with Amanitin for targeted cancer treatment.