Saporin (CAT#: ADC-P-146)

ADCs Toxins, Saporin is a plant toxin belonging to the ribosome-inactivating protein (RIP) family, a class of toxic enzymes that is widely distributed among plant genera whose activity is classically identified as rRNA N-glycosylase DNA.

Product Information

Description
ADCs Toxins, Saporin is a plant toxin belonging to the ribosome-inactivating protein (RIP) family, a class of toxic enzymes that is widely distributed among plant genera whose activity is classically identified as rRNA N-glycosylase DNA.

Classification
RNA inhibitors

Molecular Weight
29.5 kDa

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

The Saporin toxin provided by Creative Biolabs worked exceptionally well in our ADCs research. It effectively inactivated ribosomes without affecting other cell components, enhancing our results significantly. Highly recommend for those in need of reliable RIP toxins.

Excellent

We used Saporin from Creative Biolabs for targeted cell ablation experiments, and the results were outstanding. The toxin's ribosome-inactivating function worked as expected, ensuring high accuracy in our study outcomes.

Excellent

Creative Biolabs' Saporin ADCs toxin exceeded expectations. It demonstrated excellent efficacy and consistency in ribosome inactivation, contributing to reliable, reproducible data in our therapeutic antibody development.

Excellent

Saporin was an essential component in our research on targeted cancer therapies. The product's high purity and consistent activity made our experiments run smoothly and yielded precise results. Great quality!

Excellent

The Saporin toxin from Creative Biolabs played a crucial role in our ADCs project. Its ribosome-inactivating ability was highly effective, and the product arrived in perfect condition, ready for use.

Q: 1: What is Saporin and how does it work?
A: Saporin, a ribosome-inactivating protein from Saponaria officinalis seeds, disrupts protein synthesis in target cells, leading to cell death. It specifically removes an adenine from ribosomal RNA, halting protein elongation. This selectivity makes Saporin effective in targeted therapies, often linked to antibodies targeting cancer or autoimmune cells, minimizing healthy cell damage and enhancing treatment efficacy.
Q: 2: What are the benefits of using Saporin in ADC development?
A: Saporin's ability to specifically inactivate ribosomes without requiring a chemical linker makes it a valuable toxin in ADC development, offering highly targeted cytotoxicity for cancer treatment.
Q: 3: Can Saporin be used in all types of ADCs?
A: Saporin can be conjugated to specific antibodies in ADCs designed for targeted therapies, but its use depends on the compatibility of the antibody and the cancer target being studied.
Q: 4: What makes Saporin different from other ribosome-inactivating proteins (RIPs)?
A: Saporin is unique among RIPs due to its wide distribution among plant genera and its highly efficient rRNA N-glycosylase activity, making it particularly effective in halting protein synthesis.
Q: 5: What are the advantages of choosing Creative Biolabs' Saporin for ADC development?
A: Creative Biolabs provides Saporin with consistent quality and activity, ensuring reliable results in ADC research. Its potent cytotoxicity, coupled with high purity, makes it an excellent choice for developing precise and effective cancer-targeting therapies.

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