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ERBB2

Erb-b2 receptor tyrosine kinase 2(ERBB2), commonly referred to as HER2, is an epidermal growth factor (EGF) receptor family tyrosine kinase. It is also referred to as ERBB2, NEU, NGL, TKR1, CD340, MLN 19, or HER-2/neu under different circumstances and it is a unique EGF receptor. There is no reported ligand that interacts with HER2. It is not susceptible to any epidermal growth factor binding. However, HER2 forms heterodimers with other EGF receptors, especially HER1 and HER3, upon EGF binding to these receptors, and triggers downstream signaling cascades that promotes cell proliferation.

The overexpression of HER2 is associated with a variety of cancers, including gastric cancer, glioma, hereditary diffuse gastric cancer, lung cancer, ovarian cancer…. HER2 level has been used as a cancer diagnosis and due to its abundant expression in cancer tissues verses normal tissues, HER2 is an important target for antibody-based cancer immunotherapies. Herceptin, an anti-HER2 monoclonal antibody and Kadcyla, the ADC version of Herceptin, has been approved for breast cancer treatment.

Gene ID: 2064
UniProt ID: P04626