TCO-PEG4-NHS (CAT#: ADC-L-958)

TCO-PEG4-NHS is a linker for bio-conjugation that contains a terminal TCO group and a NHS group linked through a linear PEG chain.

Product Information

CAS NO
1621096-79-4

Description
TCO-PEG4-NHS is a linker for bio-conjugation that contains a terminal TCO group and a NHS group linked through a linear PEG chain.

Molecular Weight
514.56

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Creative Biolabs' TCO-PEG4-NHS made bioconjugation experiments seamless. The product was easy to handle, enabling efficient and selective labeling of our biomolecules in click chemistry reactions.

Excellent

Using TCO-PEG4-NHS from Creative Biolabs greatly facilitated our site-specific labeling processes. It provided excellent reactivity, ensuring precise conjugation in our protein modification studies.

Excellent

TCO-PEG4-NHS from Creative Biolabs proved to be an excellent reagent for bioorthogonal chemistry. It allowed us to perform efficient conjugations without affecting the biological activity of our proteins.

Excellent

Incorporating Creative Biolabs' TCO-PEG4-NHS into our experiments enhanced the efficiency of our click reactions, helping us achieve high-purity conjugates for downstream applications in a short time.

Excellent

We used TCO-PEG4-NHS from Creative Biolabs for antibody modification, and it allowed us to achieve highly specific and stable conjugation, greatly advancing our targeted therapeutic development.

Excellent

Creative Biolabs' TCO-PEG4-NHS streamlined our conjugation workflow. The ease of application and reliable performance helped us generate high-quality bioconjugates for our imaging experiments.

Q: 1: What is TCO-PEG4-NHS and its main application?
A: TCO-PEG4-NHS is a reactive linker used for bio-conjugation, enabling site-specific labeling of proteins or antibodies. It is often used in antibody-drug conjugate (ADC) development for efficient and stable linkage.
Q: 2: How does TCO-PEG4-NHS function in ADC development?
A: TCO-PEG4-NHS reacts with primary amines on antibodies, allowing the conjugation of cytotoxic drugs to antibodies. Its PEG spacer provides flexibility and reduces steric hindrance, enhancing ADC efficiency.
Q: 3: What is the advantage of using PEG spacers like PEG4 in TCO-PEG4-NHS?
A: The PEG4 spacer increases water solubility, reduces immunogenicity, and provides flexibility in the linkage between the antibody and drug, improving ADC stability and effectiveness.
Q: 4: What types of antibodies are compatible with TCO-PEG4-NHS?
A: TCO-PEG4-NHS can be conjugated to any antibody with accessible primary amines, such as lysine residues, allowing broad applicability in various ADC designs targeting different cancer types.
Q: 5: Can TCO-PEG4-NHS be used for dual conjugation in ADCs?
A: Yes, TCO-PEG4-NHS can be used in dual conjugation strategies, enabling the attachment of both cytotoxic drugs and imaging agents to the same antibody for multifunctional therapeutic approaches.

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