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Anti-ERBB2 (Trastuzumab)-Mc-MMAD ADC (CAT#: ADC-W-409)

This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a Mc linker to a MMAD. The MMAD is targeted to breast cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • ERBB2
  • Alternative Names
  • ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
  • Target Entrez Gene ID
  • 2064
  • Overview
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
  • Overview
  • Humanized Anti-ERBB2 Antibody, Trastuzumab
  • Generic name
  • Trastuzumab
  • Species Reactivity
  • Human
  • Name
  • Mc (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAD (monomethyl auristatin D)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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ADC-W-1115 Anti-ERBB2 (Pertuzumab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
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ADC-W-1114 Anti-ERBB2 (Pertuzumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-116 Anti-ERBB2 (Trastuzumab)-Gly5-modified DM1 ADC  C-terminal GS (glycine-serine) linker Gly5-modified DM1 (Gly5-modified N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
CAT# Product Name Linker Payload
ADC-W-485 Anti-EphA2 (clone 1C1)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-537 Anti-TPBG-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-491 Anti-TNFRSF17-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-478 Anti-ENPP3-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-517 Anti-TM4SF1 ( clone v1.10)-Mc-LP2 ADC Mc (maleimidocaproyl) LP2 (chemical name mc-3377)
CAT# Product Name Linker Payload
ADC-W-292 Anti-TACSTD2 (clone 7E6)-PEG6-MMAD ADC PEG6 ((Propylene Glycol)-6-propionyl) MMAD (monomethyl auristatin D)
ADC-W-290 Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-MMAD ADC AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) MMAD (monomethyl auristatin D)
ADC-W-568 Anti-TACSTD2 (clone C16)-VC-MMAD ADC VC (valine-citrulline) MMAD (monomethyl auristatin D)
ADC-W-312 Anti-TPBG (clone A1)-hydroxyl amino PEG-MMAD ADC hydroxyl amino PEG linker MMAD (monomethyl auristatin D)
ADC-W-632 Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAD ADC Aminocaproyl MMAD (monomethyl auristatin D)

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