Val-Cit-PAB-MMAE (CAT#: ADC-S-079)

Linker-Toxin SET, this set is made by MMAE conjugated to the lysosomally cleavable Val-Cit-PAB linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Product Information

CAS NO
644981-35-1

Description
Linker-Toxin SET, this set is made by MMAE conjugated to the lysosomally cleavable Val-Cit-PAB linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Molecular Weight
1123.43

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

The Val-Cit-PAB-MMAE product from Creative Biolabs has been instrumental in my antibody-drug conjugate research. The stability and high efficacy of the linker and drug conjugate exceeded expectations, resulting in consistently reliable experimental results.

Excellent

Creative Biolabs' Val-Cit-PAB-MMAE is a well-formulated compound for ADC studies. It offers excellent drug release and stability, significantly improving my research output in targeted cancer therapies.

Excellent

Using Val-Cit-PAB-MMAE in our lab yielded impressive results. The controlled drug release mechanism functioned perfectly, ensuring targeted cytotoxicity in our cell assays.

Excellent

The Val-Cit-PAB-MMAE linker from Creative Biolabs has become a key component in our ADC experiments. The product's purity and functionality ensured high efficiency in our tests, delivering potent cytotoxicity to target cells with minimal off-target effects.

Excellent

Our team has found Creative Biolabs' Val-Cit-PAB-MMAE to be an excellent choice for ADC research. Its stability and effectiveness in drug delivery have proven invaluable in developing our targeted therapies. A reliable and efficient product.

Q: 1: What is the mechanism of action of Val-Cit-PAB-MMAE?
A: Val-Cit-PAB-MMAE delivers MMAE to cells by linking it to antibodies. Once internalized by target cells, the linker is cleaved, releasing MMAE to disrupt microtubule assembly, leading to cell death.
Q: 2: What applications are best suited for using Val-Cit-PAB-MMAE?
A: Val-Cit-PAB-MMAE is best suited for use in preclinical studies of antibody-drug conjugates (ADCs) targeting various cancers, including breast, lung, and lymphoma models.
Q: 3: What are the benefits of using Val-Cit-PAB as a linker for MMAE in drug conjugates?
A: Val-Cit-PAB provides a stable, cleavable linker that remains intact in the bloodstream but is efficiently cleaved in the lysosome, ensuring precise release of MMAE at the target site within cancer cells.
Q: 4: Is Val-Cit-PAB-MMAE compatible with different antibodies, and what factors affect conjugation efficiency?
A: Val-Cit-PAB-MMAE is compatible with a variety of antibodies; however, factors such as antibody isotype, conjugation site, and linker chemistry can affect conjugation efficiency and overall ADC stability.
Q: 5: How does Val-Cit-PAB-MMAE specifically target cancer cells?
A: Val-Cit-PAB-MMAE is conjugated to monoclonal antibodies that bind to specific antigens on cancer cells, delivering the cytotoxic MMAE (monomethyl auristatin E) directly to the targeted tumor cells.

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