Atypical chemokine receptor family (ACR) is a group of heptaspanning membrane receptors with seven transmembrane domains, which are structurally homologous to chemokine G-protein coupled receptors (GPCRs). ACR family is characterized by promiscuity of ligand binding and an apparent incapability to signal following ligand binding. ACR family comprises five receptors, antigen receptor for chemokines (DARC; atypical chemokine receptor 1), C-C chemokine receptor D6 (atypical chemokine receptor 2), CXCR7 (atypical chemokine receptor 3), CC-Chemokine receptors like 1 and 2 (CCRL1 and CCRL2; atypical chemokine receptor 4 and 5), which cover among them a wide range of chemokine ligands. ACRs are involved in a number of pathophysiological processes by regulating chemokine availability and function.
These receptors have proved to be important molecular players in health and disease. And the pivotal roles that ACRs play in the context of resolving inflammatory responses, underlines these receptors as potential therapeutic targets. Here, we give further detail information for several atypical chemokine receptors for your review.
Taking advantage of our Magic™ membrane protein production platform, scientists in Creative Biolabs are focused on the preparation of these membrane proteins given above in required formats through different strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with stable cell line.
What’s more, Magic™ membrane protein antibody discovery platform at Creative Biolabs can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
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