This product is a Ramos (RA 1) B cell engineering tool based on the Niosomes (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-Brefeldin A) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FKBP5 |
| Insert Clone | BCG-3054CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Niosomes |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1660 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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