This product is a BC-1 B cell engineering tool based on the Nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (hROSA26-huIgH296-SpCas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | BC-1 |
| Target | RETN |
| Insert Clone | BGD9 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 41-150 |
| Charge (mv) | 11 to 77 |
| Total Atom Count | -61000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer; Melanoma |
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