The human immune system’s most crucial element is the complement, and its two most essential subtypes are C3 and C4. Low levels of the two subtypes indicate that the immune system of the human body is experiencing some issues. Immune system diseases including liver disease, kidney disease, systemic lupus erythematosus, and multiple sclerosis.
C3 and C4 complements are indicators for detecting immune function and diffuse connective tissue diseases, such as systemic lupus erythematosus, rheumatoid, xerosis, etc.
The clinical significance of the C3 and C4 complements
1. Hypocomplementemia has a prompting effect and clinical significance for diffuse connective tissue disease, indicating that the disease is still active.
Rheumatic diseases, especially diffuse connective tissue diseases, are mainly due to low complement, especially the consumption of C3 and C4, to determine whether the immune response is too strong, whether it is still progressing, and to access the degree of disease activity.
2. High complement levels do not mean much but point to an impaired immune system.
The treatment of low complements of C3 and C4
1. Timely application of glucocorticoids and immunosuppressants:
Low complement C3 and C4 are caused by autoimmune diseases, which require the timely application of prednisone and other glucocorticoids or the application of immunosuppressants for treatment.
2. Supplement energy substances:
Properly eat more high-quality proteins such as fish, shrimp, eggs, milk, etc. The low complement of C3 and C4 in children may be caused by malnutrition.
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