Therapeutic approaches based on extracellular vesicles (EVs) are attracting significant attention in drug delivery, immunotherapy, and regenerative medicine. However, the clinical translation of EVs is hindered by challenges such as limited yield,Read More…
On September 2, 2024, Nature Materials published a study titled “Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery.” This research challenges traditional views by revealing that tumor-secreted exosomesRead More…
Extracellular vesicles (EVs), including exosomes, encapsulate DNA, RNA, and proteins within a phospholipid bilayer. These vesicles deliver their lumenal cargo to the cytoplasm of recipient cells, influencing immune cell function. This impactRead More…
Extracellular vesicles (EVs), including exosomes, are cell-derived nano or micrometer-sized monolayer or multilayer membrane structures. EVs contain bioactive cargoes such as nucleic acids, lipids, proteins, and carbohydrates, and play a key roleRead More…
Extracellular vesicles (EVs) are a highly heterogeneous class of membrane vesicles that participate in regulating various biological processes by transporting proteins, lipids, nucleic acids, and metabolites. According to differences in size andRead More…
Exosomes are secretory vesicles with a diameter of about 30 to 150 nanometers that play an important role in human health and disease. To better understand how cells release these vesicles, researchersRead More…
Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis, constitute a class of progressive diseases with complex pathogenesis. Traditional treatments face significant challenges due to drug delivery challenges.Read More…
Extracellular vesicles (EVs) secreted by all cell types are involved in the intercellular communication, delivering regulatory factors that influence cell and tissue phenotypes in both normal and diseased tissues. Therefore, EVs representRead More…
The blood-brain barrier (BBB) poses a significant challenge to the systemic delivery of mRNA to diseased neurons.While extracellular vesicles (EVs) derived from leukocytes can traverse the BBB, efficiently loading lengthy mRNAs intoRead More…
Extracellular vesicle (EV)-based therapeutic approaches still pose challenges in clinical application due to their rapid clearance, limited residence, and low yield. Although hydrogels possess the ability to impede physiological clearance and increaseRead More…