Introduction: The Growing Need for Scalable Exosome Manufacturing Exosomes, small extracellular vesicles ranging from 30 to 150 nanometers, have gained significant traction in biomedical research and clinical development due to their remarkableRead More…
Introduction: The Growing Importance of Exosome Research Almost every cell type secretes exosomes which are extracellular vesicles measuring between 30 and 150 nanometers in diameter. Exosomes perform essential roles in cellular interactionRead More…
Melanoma is one of the most aggressive types of skin cancer, characterized by rapid progression and a high metastasis rate, with a median survival of only 3 to 11 months. Current melanomaRead More…
Small extracellular vesicles (sEVs) are nanoscale vesicles. Death receptor 5 (DR5) mediates exogenous apoptosis. Recently, scientists published a paper in Science Advances where they designed single-chain variable fragments (scFvs) that agonize DR5,Read More…
On September 2, 2024, Nature Materials published a study titled “Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery.” This research challenges traditional views by revealing that tumor-secreted exosomesRead More…
Extracellular vesicles (EVs) secreted by all cell types are involved in the intercellular communication, delivering regulatory factors that influence cell and tissue phenotypes in both normal and diseased tissues. Therefore, EVs representRead More…
Extracellular vesicle (EV)-based therapeutic approaches still pose challenges in clinical application due to their rapid clearance, limited residence, and low yield. Although hydrogels possess the ability to impede physiological clearance and increaseRead More…
Extracellular vesicles (EVs) are biological nanoparticles that mediate short- and long-distance intercellular communication, delivering bioactive payloads. Short-distance communication occurs in the interstitium, while long-distance communication necessitates transport through the blood circulation toRead More…
A recent review was published in Nature Reviews Rheumatology delves into the promising therapeutic applications of mesenchymal stromal cell extracellular vesicles (EVs) in rheumatic diseases. Rheumatic diseases comprise a diverse range ofRead More…
Non-alcoholic fatty liver disease (NAFLD) is strongly linked to various cancers, including liver, breast, prostate, pancreatic, and colorectal cancer, surpassing its association with obesity alone. Patients with fatty liver disease exhibit aRead More…