Extracellular vesicles (EVs) are biological nanoparticles that mediate short- and long-distance intercellular communication, delivering bioactive payloads. Short-distance communication occurs in the interstitium, while long-distance communication necessitates transport through the blood circulation toRead More…
Vesiclepedia (http://www.microvesicles.org) stands as a comprehensive, web-based database, offering a compilation of DNA, RNA, proteins, lipids, and metabolites that have been identified or associated with extracellular vesicles (EVs) and extracellular particles (EPs).Read More…
Effective and targeted drug delivery remains a significant challenge in modern medicine. Researchers are employing biochemical engineering approaches to repurpose extracellular vesicles (EVs) as drug delivery vehicles. Studies have demonstrated that displayingRead More…
A recent review was published in Nature Reviews Rheumatology delves into the promising therapeutic applications of mesenchymal stromal cell extracellular vesicles (EVs) in rheumatic diseases. Rheumatic diseases comprise a diverse range ofRead More…
Extracellular vesicles (EVs) have emerged as a promising avenue for advanced drug delivery. One effective strategy for loading these EVs with desired cargo involves genetically fusing a target protein to a scaffoldRead More…
Systems featuring programmable RNA molecule export capabilities hold the potential for non-destructive cellular dynamics monitoring and efficient RNA delivery to engineered cells. In a recent breakthrough, Michael B. Elowitz and Felix HornsRead More…
Recent studies have revealed that extracellular vesicles (EVs) surface molecules are often accompanied by glycan or glycosylation modifications. Researchers from the Institute of Chemistry at the Slovak National Academy of Sciences haveRead More…
Non-alcoholic fatty liver disease (NAFLD) is strongly linked to various cancers, including liver, breast, prostate, pancreatic, and colorectal cancer, surpassing its association with obesity alone. Patients with fatty liver disease exhibit aRead More…
Intercellular communication stands as a pivotal characteristic in tumor progression and metastasis. Extracellular vesicles (EVs), generated by diverse cells including tumor cells, serve as indispensable agents in cell-to-cell communication. They wield influenceRead More…
Exosomes Exosomes are single-layer membrane vesicles secreted by cells with a diameter of 30-200 nm, rich in proteins, lipids, nucleic acids, and carbohydrate complexes, and have obvious molecular heterogeneity. The production ofRead More…