Antibodies are a class of proteins that are important to the body’s immune system. Immunoglobulin G (IgG) stores memories of past infections and marks dangerous microbes so they can be destroyed byRead More…
Immunotherapy shines in tumor treatment. In 2021, more than 100 monoclonal antibody drugs have been approved. In addition to monospecific antibodies, the development of multispecific antibodies is also in full swing. AtRead More…
Therapeutic Antibody Drugs Since the first clinical application approval in 1986, more than 100 therapeutic antibody drugs have entered clinical application successively, and new antibody drugs are in the process of developmentRead More…
Introduction to antibody structure and function An antibody molecule composes of an antigen-binding fragment (Fab) and a crystallizable fragment (Fc), forming a Y-shaped structure. The Fab region is a mixed light andRead More…
Currently, the more common technical routes for lead antibody production mainly include hybridoma, antibody library, and single B cells. Among them, hybridoma technology and antibody library technology were applied earlier, and singleRead More…
Basic Structure of ADCs Antibody-drug conjugates (ADCs) are conjugates consisting of three basic components: monoclonal antibodies (which target specific tumor antigens), highly potent cytotoxic small molecule payloads, and linkers. The basic structureRead More…
The protein expression system is similar to a sophisticated instrument that continuously delivers proteins to the outside world. The central law is the simplest one which is that the terminal is theRead More…
Recently, a research paper entitled “Structural insights into the membrane microdomain organization by SPFH family proteins” was published in Cell Research. The high-resolution structure of super membrane complexes formed by two representativeRead More…
In a new study, researchers from the University of Utah, Rockefeller University, and Pennsylvania State University determined how CHMP3 variants (RetroCHMP3) discovered in mice and monkeys interfere with the replication of envelopedRead More…
The identification of drug resistance mutations in drug targets provides vital information for new drug development. Due to the fallibility of HIV-1 reverse transcriptase (RT), lentivirus transduction can lead to many typesRead More…