Antibodies are a class of proteins that are important to the body’s immune system. Immunoglobulin G (IgG) stores memories of past infections and marks dangerous microbes so they can be destroyed byRead More…
The molecular mechanism by which special antibodies protect the body against HIV infection
Neutralizing antibodies targeting HIV-1 Env have now been shown to protect against systemic infection. Recently, scientists from the University of Bochum in Germany and other institutions have discovered through research that HIVRead More…
Multispecific antibodies enhance cancer immunotherapy
Immunotherapy shines in tumor treatment. In 2021, more than 100 monoclonal antibody drugs have been approved. In addition to monospecific antibodies, the development of multispecific antibodies is also in full swing. AtRead More…
Scientists have cracked HIV’s new way of entering the host cell nucleus, which may lead to new therapeutic drugs
Human immunodeficiency virus 1 (HIV-1) is a retrovirus, and most HIV-1 infections occur on the mucosal surface of the human reproductive tract. After HIV-1 enters the nucleus of the host cell, itRead More…
Antibody sequencing provides a new path for antibody therapy research
Therapeutic Antibody Drugs Since the first clinical application approval in 1986, more than 100 therapeutic antibody drugs have entered clinical application successively, and new antibody drugs are in the process of developmentRead More…
Monoclonal Antibodies: How to Choose an IgG Subtype
Introduction to antibody structure and function An antibody molecule composes of an antigen-binding fragment (Fab) and a crystallizable fragment (Fc), forming a Y-shaped structure. The Fab region is a mixed light andRead More…
Application of Single Domain Antibodies in Cell Therapy
G protein-coupled receptor (GPCR) is a very important receptor protein on the cell surface. In the human genome, GPCR-encoding genes account for more than 2% and contain more than 800 members, makingRead More…
The road to lead antibody generation—hybridomas, antibody libraries, and single B cells
Currently, the more common technical routes for lead antibody production mainly include hybridoma, antibody library, and single B cells. Among them, hybridoma technology and antibody library technology were applied earlier, and singleRead More…
Introduction to Antibody-Drug Conjugates
Basic Structure of ADCs Antibody-drug conjugates (ADCs) are conjugates consisting of three basic components: monoclonal antibodies (which target specific tumor antigens), highly potent cytotoxic small molecule payloads, and linkers. The basic structureRead More…
Selection of Protein Expression System
The protein expression system is similar to a sophisticated instrument that continuously delivers proteins to the outside world. The central law is the simplest one which is that the terminal is theRead More…