Immunotherapy shines in tumor treatment. In 2021, more than 100 monoclonal antibody drugs have been approved. In addition to monospecific antibodies, the development of multispecific antibodies is also in full swing. AtRead More…
Basic Structure of ADCs Antibody-drug conjugates (ADCs) are conjugates consisting of three basic components: monoclonal antibodies (which target specific tumor antigens), highly potent cytotoxic small molecule payloads, and linkers. The basic structureRead More…
In the past, components of adaptive immunity were thought to play non-overlapping roles in antimicrobial host defense, with antibodies targeting pathogens in the extracellular environment and T cells responsible for eliminating intracellularRead More…
Cancer has become the second largest health threat in the world, with about 10 million people dying of cancer in 2020. For decades, cytotoxic-based chemotherapy has been the main treatment for allRead More…
Multiple myeloma is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, in a recent study published in Science Translational Medicine entitled “Selective targeting of multiple myeloma cellsRead More…
Recently, scientists at the Walter Reed Army Institute have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria. The study, led by Dr. Sheetij Dutta, theRead More…
CD38 protein, which was discovered in 1980, is a type II transmembrane glycoprotein with a size of 46 kDa. The ligand of CD38 is CD31, also known as PECAM-1, which is aRead More…
Incidence of lung cancer Lung cancer has the highest incidence of cancer in the world. According to WHO’ statistics, there are an estimated 18.1 million new cancer patients worldwide in 2018, ofRead More…
B lymphocytes can only produce a proprietary antibody against an antigen determinant, so it has the characteristics of highly specific physical and chemical properties, single biological activity, strong binding specificity with antigenRead More…
The Antibodies are secreted by plasma cells transformed from B cells, and each B cell line can produce only one specific antigenic determinant. The antibody, produced from a single cell line, isRead More…