Main steps of PROTAC to achieve intracellular protein degradation To achieve intracellular protein degradation requires multiple steps, such as cellular uptake, effective recruitment of E3 ligase, ubiquitination of target proteins, and recruitmentRead More…
In 2004, the Nobel Prize in Chemistry was awarded to Israeli scientists Aaron Sichanova, Afram Hershko and American scientist Irwin Ross for their discovery of ubiquitin-regulated protein degradation. Protein degradation is ratedRead More…
Recently, Pfizer and Arvinas jointly announced that they have reached an agreement to co-develop and promote the PROTAC protein degrader ARV-471. Arvinas will receive $650 million in upfront payments and potentially upRead More…