Monthly Archives: April 2022

22Apr/22

Review of PROTAC Targeted Degradation of Protein Kinases

April 22, 2022protac reviewsprotac, Protein Kinasesbiolabs

PROTAC consists of a flexible linker conjugating the protein of interest (POI) ligand and an E3 ligase ligand. Its action mechanism makes use of the mechanism of protein degradation induced by theRead More…

11Apr/22

E3 Ligase, Critical for PROTAC Design

April 11, 2022protac reviewsE3 ligase, protacbiolabs

A core factor of PROTAC molecules is that protein degradants can be designed rationally by selecting ligase molecules and linkers according to the target. The module that binds to E3 ligase canRead More…

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