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Category Archives: Protein Degrader Research

13Mar/25
protein degradation process(Creative Biolabs Authorized)

The Unsung Hero of Protein-Degrading Therapies: How Linker Design is Changing the Game

March 13, 2025Protein Degrader Researchprotein degradation, protein degradation linkerbiolabs

When we think about next-gen therapies that eliminate disease-causing proteins, most attention goes to the “targeting” components—the parts that bind to harmful proteins or cellular cleanup crews. But there’s a quiet powerhouseRead More…

13Feb/25
lysosome-dependent-protein-degradation-strategies

Breaking New Ground in Protein-Targeted Therapies: What’s Next for Drug Development?

February 13, 2025Protein Degrader Researchbiolabs

Drug discovery is experiencing an unobtrusive revolution. Researchers have advanced past just blocking dangerous proteins and now pursue methods to actively break them down which could enable treatments for previously untreatable diseases. The foundationRead More…

24Jan/25
Properties of interest and computational approaches in TPD.

Isolation and Evaluation of Protein Degrader Technology in the Clinical Practice of Modern Medicine: Embracing the Benefits of Protein D egrader Technology in Medicine Today

January 24, 2025Protein Degrader Researchprotein degradation, targeted protein degradationbiolabs

Introduction Targeted Protein Degradation (TPD) has become a revolutionary way to work for the treatment of many diseases, yet they have been very successful in the treatment of diseases that have beenRead More…

05Nov/24

Innovative Approaches to Targeted Protein Degradation for Drug Development

November 5, 2024Protein Degrader News, Protein Degrader Researchprotein degradation, Protein Degrader Technologybiolabs

Introduction Proteolysis-targeting chimeras are a new class of small molecules that provide alternative ways to discover drugs by leading target proteins to be selectively destroyed. In contrast to conventional inhibitors that only suppressRead More…

12Sep/24

Harnessing PhosTACs for Targeted Protein Dephosphorylation: A New Frontier in Therapeutics

September 12, 2024Protein Degrader ResearchFOXO3a, PDCD4, PhosTACs, Protein Phosphorylationbiolabs

Chen, Po-Han, et al. “Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs).” ACS chemical biology 16.12 (2021): 2808-2815. In the rapidly evolving field of drug development, targeting protein post-translational modifications (PTMs) has emergedRead More…

24Aug/24

Protein-degraders: The New Go-to For Tackling Autoimmune Issues

August 24, 2024Protein Degrader ResearchBTK inhibitors, protein targeted degradation chimera, Protein-degradersbiolabs

Protein targeted degradation chimera is an emerging protein degradation strategy that has been booming in recent years. It was first proposed by Craig Crews et al. in 2001. Its basic principle isRead More…

23Jul/24

Can Protein Degrader Therapy Be a Hope for AIDS Patients?

July 23, 2024Protein Degrader News, Protein Degrader ResearchAIDS, CRBN, Targeted Protein Degrader Therapybiolabs

Nef is an accessory protein encoded by HIV-1, HIV-2, and other primate lentiviruses and is closely related to viral replication, persistent infection, and the development of AIDS. Nef interacts with a varietyRead More…

21Apr/24

New Role Introduced: PDF-Bin, Protein Targeting the Degradation “Dumpcart”

April 21, 2024Protein Degrader ResearchATTEC, Targeted Protein Degraderbiolabs

Over the past two decades, protein-targeting degradation technologies (TPD), epitomized by Protein Degrader (proteolysis targeting chimera), have undergone rapid development and are considered one of the most promising breakthrough technologies for tacklingRead More…

22Dec/23

Researchers Have Made New Advances in the Field of Protein Degradation

December 22, 2023Protein Degrader ResearchLipoSM-Protein Degrader, Protein Degrader Delivery, Protein Researchbiolabs

ROTAC technology has advantages such as targeting non-druggable targets, high catalytic activity, and overcoming drug resistance, making it a new strategy in drug development. Traditional Protein Degrader design and synthesis require aRead More…

25Oct/23

Neuron: Revealing the Molecular Mechanism of the Spread of Toxic tau Proteins in the Brain

October 25, 2023Protein Degrader ResearchTargeted Protein Degrader, tau Proteinsbiolabs

In Alzheimer’s disease, fibrous tau pathology accumulates and spreads in the brain, leading to synaptic loss. Researchers studying mouse models have found that tau protein can spread from presynaptic to postsynaptic synapses,Read More…

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Recent Posts

  • Protein Degraders as a Promising Alternative to Traditional Chemotherapy
  • The Unsung Hero of Protein-Degrading Therapies: How Linker Design is Changing the Game
  • Breaking New Ground in Protein-Targeted Therapies: What’s Next for Drug Development?
  • Isolation and Evaluation of Protein Degrader Technology in the Clinical Practice of Modern Medicine: Embracing the Benefits of Protein D egrader Technology in Medicine Today
  • Latest Advances and Four Key Innovations in Targeted Protein Degradation

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