Glioma is a primary intracranial malignant tumor originating from glial cells or progenitor cells, accounting for 25.5% of central nervous system tumors. Clinically, the treatment of glioma mainly depends on surgical resection,Read More…
Acute lymphoblastic leukemia (ALL) is a common disease. B-ALL and T-ALL account for 85% and 15% of the two lymphatic lineages of ALL, respectively, but patients with T-ALL have poor life qualityRead More…
In the past 20 years, Protein Degrader has ushered in a period of rapid development, especially since the successful degradation of BET protein by dBET1 Protein Degrader with pomalidomide as the ligandRead More…
Induced degradation of target proteins is a new concept in drug discovery. For eukaryotes, the ubiquitin-proteasome system is the main pathway of intracellular protein degradation, which participates in more than 80% ofRead More…
Protein Degrader (Proteolysis-Targeting Chimera) technology, by linking E3 ubiquitin ligase to the target protein, leads to the ubiquitin modification of the target protein, which is broken down into peptides and amino acidsRead More…
Targeting tumor cell apoptosis and angiogenesis Apoptosis (or programmed cell death) is an evolutionarily conservative process that maintains tissue homeostasis under cellular stress, DNA damage and immune surveillance. However, cancer cells canRead More…
The occurrence and development of cancer is a complex process, which is characterized by continuous proliferation signals, avoidance of growth inhibitors, resistance to cell death, induction of angiogenesis, activation of invasion andRead More…
Protein Degrader consists of a flexible linker conjugating the protein of interest (POI) ligand and an E3 ligase ligand. Its action mechanism makes use of the mechanism of protein degradation induced byRead More…
A core factor of Protein Degrader molecules is that protein degradants can be designed rationally by selecting ligase molecules and linkers according to the target. The module that binds to E3 ligaseRead More…
Protein Degrader Concept Protein Degraders has become a new model of drug discovery, with the potential to change traditional drug discovery, and may become a new blockbuster therapy. Protein Degraders is aRead More…