Introduction to HER2 targets Human epidermal growth factor receptor 2 (HER2), also known as ERBB2, is a receptor tyrosine kinase that belongs to the ERBB receptor tyrosine kinase family together with HER1Read More…
Protein degradation is an important mechanism by which organisms regulate the amount and activity of proteins in cells. The ubiquitin-proteasome system is involved in regulating important physiological or pathological processes such asRead More…
The development concept of single domain antibody-drug conjugates (sdAb-drug conjugates) is similar to that of antibody-drug conjugates (ADCs). That is, the antibody in the ADC is replaced with a single domain antibodyRead More…
As a type of antibody with good application prospects, single domain antibodies have advantages in the diagnosis and treatment of many diseases. However, its short half-life in plasma limits its application inRead More…
Single domain antibodies have been widely used as antigen-binding domains in CAR-T due to their small size, excellent stability, high affinity, and strong manufacturing feasibility. Single domain antibody-based CAR constructs have shownRead More…
With the advent of recombinant DNA technology, many antibody fragments have been developed. Among them, camelid heavy chain variable domains (VHHs) and single chain variable domains (ScFv) are the most favored variableRead More…
An antibody-drug conjugate (ADC) is formed by linking monoclonal antibodies and small molecule cytotoxic drugs through linkers. It has both the tumor targeting of antibody drugs and the strong tumor-killing activity ofRead More…
The single-domain antibody has similar antigen binding characteristics to the traditional antibody. But, because single-domain antibodies use a single Ig variable domain for antigen recognition, they can access epitopes that cannot beRead More…
Single domain antibodies are derived from llama heavy chain-only antibodies (HCAbs). They represent a new generation of biologics with unique properties. Single domain antibodies have excellent tissue distribution, high temperature and pHRead More…
GPCR (G Protein-Coupled Receptor), the largest membrane protein family in mammalian genomes, is widely distributed in the central nervous system, immune system, cardiovascular system, and other organs and tissues, and participates inRead More…