Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-Fc-scFv) (BSTF-H264)

Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-CD3 scFv is fused to the N-terminus of Fc via a hinge region while another anti-GPNMB scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Breast cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & GPNMB

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma; Breast cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

GPNMB

Gene ID

93695

UniProt ID

Q99P91

Alternative Names

GPNMB; glycoprotein (transmembrane) nmb; ipd; Dchil; DC-HIL; transmembrane glycoprotein NMB; osteoactivin; iris pigment dispersion; dendritic cell-associated transmembrane protein; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; Glycoprotein non-metastatic b

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Human Anti-GPNMB Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-H264)

Specifications

Targets

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