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Tandem scFv

Tandem scFvs are a class of bispecific antibody fragments. Two or more moieties of scFv string together to form tandem scFv, which has 1+1 (+1…) antigen-binding valency.

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Tandem scFv

Tandem Fab

Tandem Fab is bispecific and has monovalent specificity for each antigen (1+1 antigen-binding valency).

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Tandem Fab

Diabody

Diabody is a dimer of scFv. Bispecific Diabody has monovalent specificity for each antigen (1+1 antigen-binding valency).

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Diabody

Diabody

IgG-scFv is a type of appended IgGs. It is bispecifc and can be 2+2, 2+1+1, 1+1+1+1 antigen-binding valency.

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IgG-scFv

CrossMab

CrossMab is a type of IgG-like bispecific antibody. Similarly to conventional IgG, CrossMab is bispecific and bivalent molecule, 1+1 antigen-binding valency.

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CrossMab

IgG-IgG

IgG-IgG conjugates are formed by chemical linkage. Parental antibodies with special tags can be conjugated in 1:1 to form dimers.

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IgG-IgG

Fab-IgG

Fab-IgG (also tandem Fab-Fc in the construct) is a format of appended IgGs, the IgG scaffold with Fab fragment in the N terminus. They are symmetric bispecific and tetravalent molecules, 2+2 antigen-binding valency.

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Fab-IgG

TandAb

TandAb (Tandem diabody) is a tetravalent bispecific molecule, 2+2 antigen-binding valency, consisting solely of Fv domains. They have been studied in tumor immunotherapy.

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TandAb

Single-chain Diabody

Single-chain Diabody (scDb) is a derivative of Diabody. scDb connects the first chain and the second chain of diabodies by a flexible linker, transforming the heterodimeric format of diabody into a single-chain format.

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Single-chain Diabody

Fab-Fv

Fab-Fv is a bispecific, bivalent (1+1) fragment. It is generated by a VH domain fusing to the C-terminal of a Fd fragment and a VL domain to a light chain.

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Fab-Fv

Minibody

Minibody is a bispecific, bivalent (1+1) fusion molecules. It is constructed by two scFvs fused to the CH3 domains respectively. The KIH CH3 serves as heterodimerization domain.

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Minibody

Bispecific Immunotoxin

Bispecific immunotoxins (BITs) are hybrid molecules with two specific targeting ligands fused to a toxin moiety. The toxins reach specific diseased tissue guided by the bispecific targeting molecules and perform the cytotoxic effects.

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Bispecific Immunotoxin

scFv-based Bispecific Fragments

Scfv fragments are a class of units that are commonly used to generate BsAbs. Beside the formats widely studied, there are numerous other scFv-based bispecific fragments.

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scFv-based Bispecific Fragments

Bibody

Bibody is a Fab-scFv fusion protein which utilizes Fab as the scaffold and scFv is incorporated to the C-terminus of Fd or light chain. It is a bispecific, bivalent molecule.

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Bibody

Constant Domain-extended Bispecific Fragments

CH3 domains or Fc region can be fused to bispecific fragments to extend their serum half-life.

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Constant Domain-extended Bispecific Fragments

Appended IgGs

Monospecific IgGs can be engineered by fusing additional antigen-binding units such as scFv, Fab, protein scaffolds, etc.

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Appended IgGs

Fab-scFv Fusion Proteins

Fab and scFv are two main binding units to generate bispecific antibodies. There is a class of BsAbs comprising both Fab and scFv.

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Fab-scFv Fusion Proteins

Single chain IgGs

Single chain IgGs (scIgGs) have same domain with conventional IgGs. They are bispecific and have 1+1 antigen-binding valency for each antigen.

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Single chain IgGs

BsIgG

BsIgG is a type of bispecific bivalent (1+1) antibodies. BsIgG remains the general size and structure of a conventional IgG. The technologies, such as Knob-into-holes (KIH), Charge pair, etc, facilitates the heterodimerization and assembly of bispecific IgG-like molecules.

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BsIgG

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