CACNG8 Membrane Protein Introduction

Introduction of CACNG8

The voltage-dependent calcium channel gamma-8 subunit (CACNG8) is an integral membrane protein encoded by gene CACNG8. The calcium channel gamma subunits comprise an eight-member protein family. Just like CACNG6 and CACNG7, CACNG8 is also a member of voltage, e-dependent calcium channel gamma subunits and usually has a role in stabilizing calcium channels. Its functions are similar to CACNG7.

Basic Information of CACNG8
Protein Name	Voltage-dependent calcium channel gamma-8 subunit
Gene Name	CACNG8
Aliases	Neuronal voltage-gated calcium channel gamma-8 subunit, TARP gamma-8, Transmembrane AMPAR regulatory protein gamma-8
Organism	Homo sapiens (Human)
UniProt ID	Q8WXS5
Transmembrane Times	5
Length (aa)	425
Sequence	MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV

Function of CACNG8 Membrane Protein

CACNG8 is a subunit of the calcium channel gamma subunits, and the calcium channel gamma subunits are part of voltage-gated L-type calcium channels (VLCCs). VLCCs are a group of voltage-gated ion channels found in the membrane of excitable cells. Just like CACNG7, it also has three functions. Firstly, CACNG8 can regulate the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Secondly, CACNG8 can modulate the transport and gating properties of the AMPA-selective glutamate receptor (AMPAR) by slowing down their activation, inactivation and desensitization rates and by modulating their resensitization to promote their targeting to cell membranes and synapses. Thirdly, it can show subunit-specific AMPA receptor regulation.

Fig.1 Expression pattern of CACNG8 gene in situ hybridization in mouse brain coronal sections (Gardinier, 2016)

Application of CACNG8 Membrane Protein in Literature

Fanglin Guan, et al. Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia. Scientific Reports. 2016, 6: 24914. PubMed ID: 27102562

This article reports that there are many voltage-gated L-type calcium channels (VLCC) in the brain, and genes involved in schizophrenia (SCZ), which encode VLCC subunits, play a role, we have indicated that CACNG8 may cause SCZ risk.
Burgess D.L., et al. A cluster of three novel Ca²⁺ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics. 2001, 71(3): 339-50. PubMed ID: 11170751

This article reveals that CACNG6, CACNG7 and CACNG8, are located in a tandem array on 19q13.4 and are homologous to CACNG1, CACNG5 and CACNG4.
Gardinier K.M., et al. Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. J Med Chem. 2016, 59(10): 4753-68. PubMed ID: 27067148

This article reveals that non-competitive AMPA receptor antagonists may increase the therapeutic index relative to known non-TARP dependent AMPA antagonists, and depends on the presence of TARPγ-8.
Maher M.P., et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016, 357(2): 394-414. PubMed ID: 26989142

This article reveals that The AMPA receptor modulator requires the help of the helper protein CACNG8, also known as the transmembrane AMPA receptor regulatory protein gamma 8 (TARP-γ8).

CACNG8 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CACNG5 antibody development services.

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