All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
KIR-based CAR design is a pioneering approach in the field of CAR-T therapy. It involves the incorporation of Killer-cell Immunoglobulin-like Receptors (KIRs) into the CAR construct. KIRs are a family of cell surface proteins found on natural killer (NK) cells and a subset of T cells. These receptors play a pivotal role in regulating the immune response by interacting with Human Leukocyte Antigens (HLAs) on the surface of target cells.
By integrating KIRs into CAR-T cells, our KIR-based CAR design service at Creative Biolabs aims to enhance the specificity, efficacy, and safety of CAR-T therapy. This innovative approach provides a means to fine-tune the immune response and overcome certain limitations of conventional CAR-T therapies, especially in the context of solid tumors and the challenges posed by the tumor microenvironment.
Our expert team of scientists and engineers is proficient in designing, optimizing, and validating KIR-based CAR-T constructs. The key components of our KIR CAR construction services include:
A CAR constructed using this natural multi-chain immunoreceptor design offers several compelling reasons for showing sustained efficacy in CAR-T resistant tumor models, ultimately leading to complete tumor remission:
Please contact us to advance the success of your research.
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