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The vector of anti-ERBB2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human ERBB2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-ERBB2 antibody linked to CD3ζ signaling domains. And the vector product was designed for the treatment of Lung Cancer.
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CAR Construction :
Fig.1 SPR binding sensorgrams for the interaction of HER2 wild type and mutant proteins trastuzumab. Binding data were globally fit to a simple 1∶1 interaction model (orange lines). Epa, V. C., Dolezal, O., Doughty, L., Xiao, X., Jost, C., Plückthun, A., & Adams, T. E. (2013). Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2. PloS one, 8(3), e59163. |
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CAR Construction : Trastuzumab scFv-41BB-CD28ζ
Fig.1 Representative flow cytometry dot-plot and summary data. Generation of trastuzumab-derived HER2-specific human CAR T cells, characterization of their targets and their in vitro anti-tumor function. Szöőr, Á., Tóth, G., Zsebik, B., Szabó, V., Eshhar, Z., Abken, H., & Vereb, G. (2020). Trastuzumab derived HER2-specific CARs for the treatment of trastuzumab-resistant breast cancer: CAR T cells penetrate and eradicate tumors that are not accessible to antibodies. Cancer letters, 484, 1–8. |
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