Comparative Protein Structure Modeling

Creative Biolabs has long been concentrated on protein engineering and development. Based on vast experience and solid technical strength, our protein engineering services have always been at the leading level in the industry. With the progress of biotechnology and the improvement of advanced technology platform, we currently provide customized or one-stop comparative modeling services for the prediction of target protein structure to clients all over the world.

What Is Comparative Protein Structure Modeling?

Comparative modeling of protein structure, also known as homology modeling or template-based modeling, is a useful tool for protein structure prediction based on the theoretical foundation that if two sequences of proteins are highly similar, their respective structures share a similarity. That is to say, protein structure comparative modeling is to construct a target protein model according to its amino acid sequence and an experimentally determined three-dimensional (3D) structure of a related homologous protein (namely templates).

Generally, comparative modeling of protein structure is the most accurate computational method for protein model prediction, which mainly includes four processes: (i) target identification, identifying the similarity between the target protein and determined structures; (ii) alignment of target sequence with the template; (iii) target model construction using the aligned template structure; and (iv) model refinement and evaluation.

Fig.1 General steps in comparative protein structure modeling. (Eswar, 2006)

Services

Currently, comparative modeling is suggested to be the most reliable and well-developed computational method for protein structures’ prediction. Among these structural prediction approaches, comparative modeling has been demonstrated to provide 3D structures and information with the highest accuracy in a lower cost and time-saving manner. Therefore, protein structure prediction based on comparative modeling has been widely applied for scientific researches and drug discovery.

Fig.2 Specific steps in homology modeling. (Muhammed, 2019)

Making full use of the advantages of advanced tools and servers, Creative Biolabs is dedicated to providing professional comparative modeling services to assist our customers to construct and analyze the 3D structure of the interested protein. Advantages of our protein structure comparative modeling services mainly include but not limited to:

A massive protein information resource for sequence query
Single and multiple template(s) identification and selection
Repeated iterative modeling
Optimization of side chains and ring regions
Available to complex and multi-oligomeric proteins
One-stop model construction and quality evaluation by multiple criteria

Scientists at Creative Biolabs are professional in comparative protein structure modeling to meet all kinds of project expectations and requirements. We are happy to work with you step by step so as to ensure that the most satisfactory outcome can be acquired. If you are interested in our services, contact us to discuss your requirements.

References

Eswar, N.; et al. Comparative Protein Structure Modeling Using Modeller. Current protocols in bioinformatics. 2006, 15(1): 5-6.
Muhammed, M.T.; Aki-Yalcin, E. Homology modeling in drug discovery: overview, current applications, and future perspectives. Chemical biology & drug design. 2019, 93(1): 12-20.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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