Anti-ALDH2 Aptamer SELEX Service(Cat#: CTApt-1127)
This is an aptamer development services to screening aptamers binds to the ALDH2 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ALDH2 |
| Alternative Names |
Aldehyde Dehydrogenase 2 Family Member; Aldehyde Dehydrogenase 2 Family (Mitochondrial) ; Aldehyde Dehydrogenase, Mitochondrial; ALDH Class 2; EC 1.2.1.3; ALDH-E2; ALDHI; ALDM; Nucleus-Encoded Mitochondrial Aldehyde Dehydrogenase 2; Epididymis Secretory Sperm Binding Protein; Acetaldehyde Dehydrogenase 2; Liver Mitochondrial ALDH; EC 1.2.1; ALDH2; |
| Gene ID |
217 |
| UniProt ID |
P05091 |
| Target Overview |
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
